Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidine | Rattus norvegicus | - |
histamine + CO2 | - |
? | |
L-histidine | Rattus norvegicus Sprague-Dawley | - |
histamine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P16453 | - |
- |
Rattus norvegicus Sprague-Dawley | P16453 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
hypothalamus | - |
Rattus norvegicus | - |
additional information | immunolocalization of histamine, with rabbit anti-L-histidine decarboxylase (HDC) antiserum, within the tuberomammillary nucleus is validated using carbodiimide. Rapid eye movement sleep deprivation (REM-SD) increases immunoreactive L-histidine decarboxylase by day 5, and it remains elevated in both dorsal and ventral aspects of the tuberomammillary complex | Rattus norvegicus | - |
neuron | neurons of the tuberomammillary nucleus of the posterior hypothalamus | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidine | - |
Rattus norvegicus | histamine + CO2 | - |
? | |
L-histidine | - |
Rattus norvegicus Sprague-Dawley | histamine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDC | - |
Rattus norvegicus |
L-Histidine decarboxylase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | rapid eye movement sleep deprivation (REM-SD) increases immunoreactive L-histidine decarboxylase by day 5, and it remains elevated in both dorsal and ventral aspects of the tuberomammillary complex | up |
General Information | Comment | Organism |
---|---|---|
metabolism | L-histidine decarboxylase is the rate-limiting enzyme for histamine biosynthesis | Rattus norvegicus |
physiological function | L-histidine decarboxylase (HDC) is the enzyme responsible for histamine biosynthesis in tuberomammillary nucleus (TMN) neurons of the posterior hypothalamus, the rate-limiting enzyme for histamine biosynthesis might be upregulated during chronic rapid eye movement sleep deprivation (REM-SD) because histamine plays a major role in maintaining wakefulness. Upregulation of L-HDC within the tuberomammillary complex during chronic REM-SD is responsible for maintaining wakefulness. Chronic loss of sleep causes the rat to manifest a number of pathologies or syndromes | Rattus norvegicus |