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Literature summary for 4.1.1.22 extracted from

  • Gutowska-Owsiak, D.; Greenwald, L.; Watson, C.; Selvakumar, T.A.; Wang, X.; Ogg, G.S.
    The histamine-synthesizing enzyme histidine decarboxylase is upregulated by keratinocytes in atopic skin (2014), Br. J. Dermatol., 171, 771-778 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
quantitative PCR enzyme expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidine Homo sapiens
-
 histamine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P19113
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis
-
 Homo sapiens
-
HaCaT cell
-
 Homo sapiens
-
keratinocyte two-dimensional culture Homo sapiens
-
additional information keratinocytes express abundant HDC protein, and the levels increase in atopic skin Homo sapiens
-
skin atopic Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine
-
 Homo sapiens histamine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
HDC
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ultraviolet B and surfactant exposure induce the expression of histamine-synthesizing enzyme histidine decarboxylase in keratinocytes. Lipopolysaccharide, house dust mite (HDM) extract, and cytokines, which are implicated in allergic inflammation, promote the expression of the enzyme and upregulate histamine levels in keratinocytes up

General Information

General Information Comment Organism
malfunction filaggrin expression in cultured keratinocytes increased following histamine depletion. Histidine decarboxylase expression is increased in the epidermis of patients with eczema Homo sapiens
physiological function lipopolysaccharide, house dust mite (HDM) extract, and cytokines, which are implicated in allergic inflammation, promote the expression of the enzyme and upregulate histamine levels in keratinocytes. Actively produced histamine influences keratinocyte differentiation, suggesting functional relevance of the axis to atopic dermatitis. HDC expression in keratinocytes is increased in atopic dermatitis Homo sapiens