Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.22 extracted from

  • Wu, F.; Christen, P.; Gehring, H.
    A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase (2011), FASEB J., 25, 2109-2122.
    View publication on PubMed
Search for more literature for 4.1.1.22

General Stability

General Stability Organism
HDC is a short-lived enzyme with a half-life of 1-2 h Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(-)-epigallocatechin 3-gallate
-
 Homo sapiens
alpha-Fluoromethylhistidine
-
 Homo sapiens
L-His-L-Phe
-
 Homo sapiens
additional information 1-metylhistidine, L-phenylalanine, L-tryptophan, tert-butyloxycarbonyl-modified ornithine, and tert-butyloxycarbonyl-modified alpha,gamma-diaminobutyric acid do not inhibit human HDC in mast cells and cell extracts significantly Homo sapiens
N-pyridoxyl-L-histidine methyl ester 60% inhibition at 0.2 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidine Homo sapiens
-
 histamine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mast cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine
-
 Homo sapiens histamine + CO2
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
HDC
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 12-O-tetradecanoylphorbol-13-acetate induces HDC in mast cells up