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Literature summary for 4.1.1.22 extracted from

  • Chang, G.W.; Snell, E.E.
    Histidine decarboxylase (Lactobacillus 30a) (1971), Methods Enzymol., 17B, 663-667.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
pyruvate contains several functionally essential pyruvate residues, covalently bound through an amide linkage to a Phe residue of the peptide chain. The free carbonyl group of these pyruvate residues undergoes Schiff base formation with His as part of the catalytic process Lactobacillus sp.

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Lactobacillus sp.

General Stability

General Stability Organism
inactivated by freezing and thawing Lactobacillus sp.

Inhibitors

Inhibitors Comment Organism Structure
imidazole competitively inhibited Lactobacillus sp.
KCN non-competitive Lactobacillus sp.
PCMB
-
Lactobacillus sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
9000
-
x * 9000 + x * 29700, the larger subunit contains a pyruvate residue Lactobacillus sp.
29700
-
x * 9000 + x * 29700, the larger subunit contains a pyruvate residue Lactobacillus sp.
190000
-
-
Lactobacillus sp.

Organism

Organism UniProt Comment Textmining
Lactobacillus sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Lactobacillus sp.

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
69
-
-
Lactobacillus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-Methylhistidine very poor substrate Lactobacillus sp. 1-Methylhistamine
-
?
2-Thiolhistidine very poor substrate Lactobacillus sp. 1-Thiolhistamine
-
?
3-Methylhistidine very poor substrate Lactobacillus sp. 2-Methylhistamine
-
?
beta-(1,2,4-Triazole-3)-Ala very poor substrate Lactobacillus sp. ?
-
?
beta-(Pyridyl-2)-Ala very poor substrate Lactobacillus sp. ?
-
?
beta-(Thiazole-2)-Ala very poor substrate Lactobacillus sp. ?
-
?
L-His
-
Lactobacillus sp. Histamine + CO2
-
?

Subunits

Subunits Comment Organism
? x * 9000 + x * 29700, the larger subunit contains a pyruvate residue Lactobacillus sp.