Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-difluoromethylarginine | DFMA, a suicide inhibitor, at 5 mM for 72 h, it inhibits ADC activity. DFMA, inhibits ADC activity in both supernatant and pellet fractions (43% and 26% respectively) | Chlamydomonas reinhardtii | |
additional information | alpha-difluoromethylornithine, DFMO, a suicide inhibitor, does not inhibit ADC activity | Chlamydomonas reinhardtii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | the enzyme is found in the soluble and the pellet fractions | Chlamydomonas reinhardtii | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine | Chlamydomonas reinhardtii | - |
agmatine + CO2 | - |
? | |
L-arginine | Chlamydomonas reinhardtii CC-125 | - |
agmatine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlamydomonas reinhardtii | - |
and CC-406 cell-wall mutant | - |
Chlamydomonas reinhardtii CC-125 | - |
and CC-406 cell-wall mutant | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine | - |
Chlamydomonas reinhardtii | agmatine + CO2 | - |
? | |
L-arginine | - |
Chlamydomonas reinhardtii CC-125 | agmatine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADC | - |
Chlamydomonas reinhardtii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Chlamydomonas reinhardtii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Chlamydomonas reinhardtii |
General Information | Comment | Organism |
---|---|---|
evolution | ODC is the major route to polyamine formation in the Chlamydomonas CC-406 cell-wall mutant, in contrast to the preferential ADC route reported for Chlorella vulgaris, suggesting that significant species differences exist in biosynthetic pathways which modulate endogenous polyamine levels in green algae | Chlamydomonas reinhardtii |
metabolism | putrescine is the major polyamine in both free (88%) and membrane-bound fractions (93%) in Chlamydomonas reinhardtii, while norspermidine is the next most abundant in these fractions accounting for 11% and 6%, respectively. Low levels of diaminopropane, spermidine and spermine are also observed although no cadaverine or norspermine are detected. Ornithine decarboxylase (ODC, EC 4.1.1.17) activity is almost five times higher than arginine decarboxylase (ADC) and is the major route of putrescine synthesis | Chlamydomonas reinhardtii |