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Literature summary for 4.1.1.19 extracted from

  • Sakanaka, M.; Sugiyama, Y.; Nara, M.; Kitakata, A.; Kurihara, S.
    Functional analysis of arginine decarboxylase gene speA of Bacteroides dorei by markerless gene deletion (2018), FEMS Microbiol. Lett., 365, fny003 .
    View publication on PubMed
Search for more literature for 4.1.1.19

Protein Variants

Protein Variants Comment Organism
additional information marker-less gene speA deletion by by double-crossover recombination, construction of a double knockout DELTAtdk/DELTAspeA mutant strain MS531 by knockout of gene speA in DELTAtdk strain MS416. DELTAtdk strains show 5-fluoro-2'-deoxyuridine resistance. Mutant DELTAtdk/DELTAspeA strain MS531 shows a severe growth defect in polyamine-reduced medium Phocaeicola dorei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine Phocaeicola dorei
-
 agmatine + CO2
-
 ?
L-arginine Phocaeicola dorei JCM 13471
-
 agmatine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Phocaeicola dorei A0A076IP90
-
-
Phocaeicola dorei JCM 13471 A0A076IP90
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
 Phocaeicola dorei agmatine + CO2
-
 ?
L-arginine
-
 Phocaeicola dorei JCM 13471 agmatine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
SpeA
-
 Phocaeicola dorei

General Information

General Information Comment Organism
malfunction mutant DELTAtdk/DELTAspeA strain MS531 shows a severe growth defect in polyamine-reduced medium. Disruption of polyamine biosynthetic genes including speA leads to delayed growth in various bacterial species. In contrast to the presence of intracellular spermidine as the sole polyamine in wild-type strain JCM 13471 and DELTA tdk mutant strain MS416, spermidine is barely detected in MS531. The remaining intracellular spermidine level in MS531 may be attributable to the spermidine import from polyamine-reduced medium via a predicted ATP-binding cassette transporter of spermidine, PotABCD Phocaeicola dorei
physiological function gene speA encodes a putative arginine decarboxylase, an enzyme necessary for spermidine biosynthesis in cells Phocaeicola dorei