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Literature summary for 4.1.1.19 extracted from

  • Maruri-Lopez, I.; Jimenez-Bremont, J.F.
    Hetero- and homodimerization of Arabidopsis thaliana arginine decarboxylase AtADC1 and AtADC2 (2017), Biochem. Biophys. Res. Commun., 484, 508-513 .
    View publication on PubMed
Search for more literature for 4.1.1.19

Cloned(Commentary)

Cloned (Comment) Organism
gene ADC1, recombinant heterologous expression of GFP-tagged isozyme ADC1 as homodimers in Nicotiana benthamiana using the Agrobacterium tumefaciens GV3101/pMP90 strain for transformation. The green fluorescence of GFP-AtADC1 fusion is slightly present in the cytosol and it colocalized with the red auto-fluorescence of chlorophyll channel in Nicotiana benthamiana leaf epidermal cells Arabidopsis thaliana
gene ADC2, recombinant expression as GFP-tagged protein in Arabidopsis thaliana, recombinant heterologous expression in Nicotiana benthamiana in using the Agrobacterium tumefaciens GV3101/pMP90 strain for transformation, the GFP-AtADC2 fluorescence occurs in the cytosol, and it colocalizes with the red autofluorescence of chlorophyll of tobacco leaf epidermal cells Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-
cytosol
-
 Arabidopsis thaliana 5829
-
additional information the Arabidopsis thaliana arginine decarboxylase enzymes exhibit a dual subcellular localization both in the cytosol and chloroplast. The isozymes AtADC1 and AtADC2 are able to form homodimers in the cytosol and chloroplast. The formation of AtADC1/AtADC2 heterodimers occurs with similar subcellular localization than homodimers. Both ADC proteins are located in the same cell compartments, and they are able to form protein interaction complexes with each other Arabidopsis thaliana
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine Arabidopsis thaliana
-
 agmatine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O23141
-
-
Arabidopsis thaliana Q9SI64
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis abaxial epidermis Arabidopsis thaliana
-
leaf
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
 Arabidopsis thaliana agmatine + CO2
-
 ?

Subunits

Subunits Comment Organism
dimer isozymes AtADC1 and AtADC2 are able to form homodimers in the cytosol and chloroplast. The formation of AtADC1/AtADC2 heterodimers occurs with similar subcellular localization than homodimers. Both ADC proteins are located in the same cell compartments, and they are able to form protein interaction complexes with each other Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
ADC1
-
 Arabidopsis thaliana
ADC2
-
 Arabidopsis thaliana
ATADC1
-
 Arabidopsis thaliana
AtADC2
-
 Arabidopsis thaliana
SPE1
-
 Arabidopsis thaliana
SPE2
-
 Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
additional information isozymes AtADC1 and AtADC2 are able to form homodimers in the cytosol and chloroplast. The formation of AtADC1/AtADC2 heterodimers occurs with similar subcellular localization than homodimers. Both ADC proteins are located in the same cell compartments, and they are able to form protein interaction complexes with each other Arabidopsis thaliana
physiological function the arginine decarboxylase enzyme (ADC) carries out the production of agmatine from arginine, which is the precursor of the first polyamine known as putrescine. Subsequently, putrescine is turned into the higher polyamines, spermidine and spermine. In Arabidopsis thaliana polyamine production occurs only from arginine, and this step is initiated by two ADC paralogues, AtADC1 and AtADC2. Polyamine production is essential for Arabidopsis thaliana life cycle Arabidopsis thaliana