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Literature summary for 4.1.1.19 extracted from

  • Burrell, M.; Hanfrey, C.C.; Murray, E.J.; Stanley-Wall, N.R.; Michael, A.J.
    Evolution and multiplicity of arginine decarboxylases in polyamine biosynthesis and essential role in Bacillus subtilis biofilm formation (2010), J. Biol. Chem., 285, 39224-39238.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Bacillus subtilis
expressed in Escherichia coli BL21(DE3) cells Clostridioides difficile
expressed in Escherichia coli BL21(DE3) cells Chloroflexus aurantiacus
expressed in Escherichia coli BL21(DE3) cells Gramella forsetii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.59
-
L-arginine at pH 6.5, 70°C Chloroflexus aurantiacus
0.63
-
L-arginine at pH 7.5, 37°C Bacillus subtilis
0.73
-
L-arginine at pH 7.5, 60°C Clostridioides difficile
1.1
-
L-arginine at pH 7.5, 70°C Bacillus subtilis
2.2
-
L-arginine at pH 8.5, 30°C Gramella forsetii
7.5
-
L-ornithine at pH 7.5, 70°C Bacillus subtilis

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Bacillus subtilis 168
-
-
-
Chloroflexus aurantiacus
-
-
-
Chloroflexus aurantiacus J-10-fl
-
-
-
Clostridioides difficile
-
-
-
Clostridioides difficile 630
-
-
-
Gramella forsetii
-
-
-
Gramella forsetii KT0803
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap Chelating HP column chromatography Bacillus subtilis
HiTrap Chelating HP column chromatography Clostridioides difficile
HiTrap Chelating HP column chromatography Chloroflexus aurantiacus
HiTrap Chelating HP column chromatography Gramella forsetii

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.39
-
at pH 7.5, 37°C Gramella forsetii
1.5
-
at pH 7.5, 37°C Chloroflexus aurantiacus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
Bacillus subtilis agmatine + CO2
-
?
L-arginine
-
Clostridioides difficile agmatine + CO2
-
?
L-arginine
-
Chloroflexus aurantiacus agmatine + CO2
-
?
L-arginine
-
Gramella forsetii agmatine + CO2
-
?
L-arginine
-
Bacillus subtilis 168 agmatine + CO2
-
?
L-arginine
-
Chloroflexus aurantiacus J-10-fl agmatine + CO2
-
?
L-arginine
-
Clostridioides difficile 630 agmatine + CO2
-
?
L-arginine
-
Gramella forsetii KT0803 agmatine + CO2
-
?
L-lysine activity is 1.9% of that with L-arginine Chloroflexus aurantiacus 1,5-diaminopentane + CO2
-
?
L-lysine activity is 1.9% of that with L-arginine Chloroflexus aurantiacus J-10-fl 1,5-diaminopentane + CO2
-
?
L-ornithine very low activity Bacillus subtilis 1,4-diaminobutane + CO2
-
?
L-ornithine activity is 1.4% of that with L-arginine Chloroflexus aurantiacus 1,4-diaminobutane + CO2
-
?
L-ornithine very low activity Bacillus subtilis 168 1,4-diaminobutane + CO2
-
?
L-ornithine activity is 1.4% of that with L-arginine Chloroflexus aurantiacus J-10-fl 1,4-diaminobutane + CO2
-
?
meso-diaminopimelate activity is less than 2% of that with L-arginine Chloroflexus aurantiacus ?
-
?
meso-diaminopimelate activity is less than 2% of that with L-arginine Chloroflexus aurantiacus J-10-fl ?
-
?

Synonyms

Synonyms Comment Organism
ADC
-
Bacillus subtilis
ADC
-
Clostridioides difficile
ADC
-
Chloroflexus aurantiacus
ADC
-
Gramella forsetii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Gramella forsetii
75
-
optimum temperature at above 75°C Bacillus subtilis
80
-
ADC is most active at temperatures above 80°C Chloroflexus aurantiacus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
70 80 at 70°C, full enzyme activity is retained, even after 30 min of incubation. Enzyme activity is almost completely abolished within 5 min by incubating the enzyme at 80°C Chloroflexus aurantiacus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.025
-
L-arginine at pH 7.5, 60°C Clostridioides difficile
0.04
-
L-ornithine at pH 7.5, 70°C Bacillus subtilis
0.21
-
L-arginine at pH 7.5, 37°C Bacillus subtilis
0.48
-
L-arginine at pH 8.5, 30°C Gramella forsetii
1.4
-
L-arginine at pH 7.5, 70°C Bacillus subtilis
11
-
L-arginine at pH 6.5, 70°C Chloroflexus aurantiacus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Chloroflexus aurantiacus
7.7
-
-
Bacillus subtilis
8.5
-
-
Gramella forsetii

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Bacillus subtilis
pyridoxal 5'-phosphate
-
Clostridioides difficile
pyridoxal 5'-phosphate
-
Chloroflexus aurantiacus
pyridoxal 5'-phosphate
-
Gramella forsetii

General Information

General Information Comment Organism
physiological function the Bacillus subtilis biosynthetic aspartate aminotransferase fold arginine decarboxylase is essential for biofilm formation Bacillus subtilis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.0056
-
L-ornithine at pH 7.5, 70°C Bacillus subtilis
0.035
-
L-arginine at pH 7.5, 60°C Clostridioides difficile
0.22
-
L-arginine at pH 8.5, 30°C Gramella forsetii
0.34
-
L-arginine at pH 7.5, 37°C Bacillus subtilis
1.3
-
L-arginine at pH 7.5, 70°C Bacillus subtilis
18
-
L-arginine at pH 6.5, 70°C Chloroflexus aurantiacus