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Literature summary for 4.1.1.19 extracted from
- Characterization of arginine decarboxylase in rat brain and liver: distinction from ornithine decarboxylase (2000), J. Neurochem., 74, 2201-2208.
General Stability
| General Stability | Organism |
|---|---|
| freeze-thawing or lyophilization completely inactivates | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | IC50: 0.8 mM | Rattus norvegicus |  |
| Co2+ | - |
Rattus norvegicus | |
| additional information | no inhibition by DL-alpha-difluoromethylornithine | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.75 | - |
L-Arg | pH 8.0, 30°C | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial membrane | most activity is associated with | Rattus norvegicus | 31966 | - |
| additional information | no activity in cytosol | Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | about 5% of the activity in aorta | Rattus norvegicus | - |
| aorta | highest activity of all tissues tested | Rattus norvegicus | - |
| brain | about 40% of the activity in aorta | Rattus norvegicus | - |
| intestine | about 40% of the activity in aorta | Rattus norvegicus | - |
| kidney | about 85% of the activity in aorta | Rattus norvegicus | - |
| liver | about 75% of the activity in aorta | Rattus norvegicus | - |
| stomach | about 60% of the activity in aorta | Rattus norvegicus | - |
| testis | about 15% of the activity in aorta | Rattus norvegicus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 50% loss of activity after overnight storage of membrane suspension | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arginine | - |
Rattus norvegicus | agmatine + CO2 | - |
? | |
| L-Orn | - |
Rattus norvegicus | Putrescine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADC | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
- |
Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | - |
4 h, 80% loss of activity in mitochondrial/synaptosomal membranes of brain | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.3 | - |
- |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.8 | - |
IC50: 0.8 mM | Rattus norvegicus | Ca2+ | |
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Release 2023.1 (January 2023)
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