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Literature summary for 4.1.1.18 extracted from

  • Wang, D.; Zhao, L.; Jiang, J.; Liu, J.; Wang, D.; Yu, X.; Wei, Y.; Ouyang, Z.
    Cloning, expression, and functional analysis of lysine decarboxylase in mulberry (Morus alba L.) (2018), Protein Expr. Purif., 151, 30-37 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene ldc, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, recombinant expression of the soluble His-tagged enzyme in Escherichia coli strain BL21(DE3), quantitative real-time reverse transcription PCR enzyme expression analysis Morus alba

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0192
-
L-lysine recombinant His-tagged enzyme, pH 8.0, 37°C Morus alba

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine Morus alba
-
cadaverine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Morus alba A0A2Z4EVE5
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant soluble His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography and dialysis Morus alba

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Morus alba
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine
-
Morus alba cadaverine + CO2
-
?

Subunits

Subunits Comment Organism
? x * 24000, recombinant His-tagged enzyme, SDS-PAGE Morus alba

Synonyms

Synonyms Comment Organism
LDC
-
Morus alba
MaLDC
-
Morus alba

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Morus alba

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Morus alba

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Morus alba

General Information

General Information Comment Organism
physiological function lysine decarboxylase MaLDC is involved in the biosynthesis of DNJ alkaloids. 1-Deoxynojirimycin (DNJ) is the main bioactive compound of Morus alba and has pharmacological effects in humans, including blood sugar level regulation and antiviral activity. The enzyme expression is correlated with DNJ content in leaves Morus alba