Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.18 extracted from

  • Wang, S.; Wan, B.; Zhang, L.; Yang, Y.; Guo, L.H.
    In vitro inhibition of lysine decarboxylase activity by organophosphate esters (2014), Biochem. Pharmacol., 92, 506-516 .
    View publication on PubMed
Search for more literature for 4.1.1.18

Inhibitors

Inhibitors Comment Organism Structure
2-ethylhexyl diphenyl phosphate
-
 Bacterium cadaveris
Acridine orange
-
 Bacterium cadaveris
cucurbit[7]uril CB7 Bacterium cadaveris
guanosine 3'-diphosphate
-
 Bacterium cadaveris
guanosine 5'-diphosphate
-
 Bacterium cadaveris
additional information inhibitory effect of organophosphate esters (OPEs) with aromatic, alkyl or chlorinated alkyl substituents on the activity of lysine decarboxylase (LDC) is assessed quantitatively with an economic and label-free fluorescence sensor and cell assay. Molecular docking analysis of the LDC/OPE complexes reveals that different binding modes contribute to the difference in their inhibitory effect. No inhibition by tris(2-ethylhexyl) phosphate, tributoxyethyl phosphate, tri-n-butyl phosphate, tri-n-propyl phosphate, triethyl phosphate, and trimethyl phosphate. In vivo cytotoxic effect of the compounds in Rattus norvegicus PC-12 cells, overview Bacterium cadaveris
tri(2-chloro-1-(chloromethyl)ethyl) phosphate
-
 Bacterium cadaveris
tri(2-chloroethyl) phosphate
-
 Bacterium cadaveris
tri-m-cresyl phosphate
-
 Bacterium cadaveris
triphenyl phosphate
-
 Bacterium cadaveris
tris(2-chloroisopropyl)phosphate
-
 Bacterium cadaveris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine Bacterium cadaveris
-
 cadaverine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Bacterium cadaveris
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine
-
 Bacterium cadaveris cadaverine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
LDC
-
 Bacterium cadaveris

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bacterium cadaveris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Bacterium cadaveris

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Bacterium cadaveris