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Literature summary for 4.1.1.17 extracted from

  • Kim, H.I.; Schultz, C.R.; Buras, A.L.; Friedman, E.; Fedorko, A.; Seamon, L.; Chandramouli, G.V.R.; Maxwell, G.L.; Bachmann, A.S.; Risinger, J.I.
    Ornithine decarboxylase as a therapeutic target for endometrial cancer (2017), PLoS ONE, 12, e0189044 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.17

Application

Application Comment Organism
diagnostics ODC1 expression is associated with worse overall survival and increased recurrence in three endometrial cancer gene expression datasets Homo sapiens
medicine ornithine decarboxylase is a therapeutic target for endometrial cancer. Some endometrial cancers appear particularly sensitive to DL-alpha-difluromethylornithine and the polyamine pathway in endometrial cancers in general and specifically those most likely to suffer adverse clinical outcomes can be targeted for effective treatment, chemoprevention or chemoprevention of recurrence Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene ODC1, quantitative real-time PCR enzyme expression analysis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
DL-alpha-difluoromethylornithine DFMO, an irreversible suicide inhibitor. DFMO inhibits growth of endometrial cancer cells in vitro and DFMO treatment significantly reduces endometrial tumor growth in vivo Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Homo sapiens
-
 putrescine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P11926
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ACI-45 cell
-
 Homo sapiens
-
ECC-1 cell endometrioid cell Homo sapiens
-
EM E6/E7 TERT1 cell normal immortalized endometrial epithelial cells Homo sapiens
-
additional information ornithine decarboxylase (ODC) is often overexpressed in cancers and contributes to polyamine-induced cell proliferation. Quantitative real-time PCR enzyme expression analysis in a validation cohort of 60 endometrial cancers, overview Homo sapiens
-
uterine endometrial cancer cell ODC1 is highly expressed in endometrial cancers, ncreased expression of ODC1 in late stage and in higher grade cancers Homo sapiens
-
uterine endometrium ODC1 is highly expressed in endometrial cancers Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Homo sapiens putrescine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ODC
-
 Homo sapiens
ODC1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis and involved in the production of putrescine through the decarboxylation of ornithine. ODC is often overexpressed in cancerous tissues and contributes to cell proliferation and tumor growth through generation of increased polyamines including not only putrescine but also the higher-order polyamines spermidine and spermine. The ODC1 gene is a direct target of MYC and related MYCN and a bona fide oncogene that can transform cells. ODC1 expression in endometrial cancers is associated with shorter time to recurrence and decreased survival Homo sapiens