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Literature summary for 4.1.1.17 extracted from

  • Gamat, M.; Malinowski, R.L.; Parkhurst, L.J.; Steinke, L.M.; Marker, P.C.
    Ornithine decarboxylase activity is required for prostatic budding in the developing mouse prostate (2015), PLoS ONE, 10, e0139522 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.17

Activating Compound

Activating Compound Comment Organism Structure
additional information in the adult prostate, ornithine decarboxylase activity is androgen-dependent Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
DL-alpha-difluoromethylornithine DFMO, an irreversible suicide inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Mus musculus
-
 putrescine + CO2
-
 ?
L-ornithine Mus musculus C57/BL6
-
 putrescine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57/BL6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo ornithine decarboxylase protein is expressed in the urogenital sinus (UGS) epithelium of the male and female embryo prior to prostate development, and expression continues in prostatic epithelial buds as they emerge from the UGS Mus musculus
-
epithelium
-
 Mus musculus
-
additional information ornithine decarboxylase co-localizes with vimentin in the developing urogenital sinus. Immunohistochemic localization analysis, overview Mus musculus
-
prostate gland ornithine decarboxylase protein is expressed in the epithelium of the ventral, dorsolateral and anterior lobes of the adult mouse prostate Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Mus musculus putrescine + CO2
-
 ?
L-ornithine
-
 Mus musculus C57/BL6 putrescine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ODC
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus ornithine decarboxylase mRNA decreases in the prostate upon castration down
Mus musculus ornithine decarboxylase mRNA increases in the prostate upon administration of androgens up

General Information

General Information Comment Organism
malfunction inhibiting ornithine decarboxylase using DL-alpha-difluromethylornithine in urogenital sinus (UGS) organ culture blocks the induction of prostatic buds by androgens, and significantly decreases expression of key prostate transcription factor, Nkx3.1, by androgens. DL-alpha-Difluromethylornithine also significantly decreases the expression of developmental regulatory gene Notch1. Other genes implicated in prostatic development, including Sox9, Wif1 and Srd5a2, are unaffected by the inhibitor. Inhibiting ornithine decarboxylase using pharmacologic agents such as alpha-difluromethylornithine or ablating Odc1 using a genetic approach renders pregnant mice unable to carry pups to term Mus musculus
metabolism ornithine decarboxylase catalyzes the first and rate-limiting step in polyamine synthesis Mus musculus
physiological function the first and rate-limiting step in polyamine synthesis is catalyzed by the enzyme ornithine decarboxylase which is encoded by the gene Odc1. Ornithine decarboxylase catalyzes the conversion of L-ornithine to putrescine. Ornithine decarboxylase activity is required for prostatic budding in the developing mouse prostate. Odc1 and polyamines are required for androgens to exert their effect in mediating prostatic bud induction, and are required for the expression of a subset of prostatic developmental regulatory genes including Notch1 and Nkx3.1. Testosterone administered to castrated male mice restores prostate secretory activity, whereas administering testosterone and the ornithine decarboxylase inhibitor DL-alpha-difluromethylornithine (DFMO) to castrated males does not restore prostate secretory activity, suggesting that polyamines are required for androgens to exert their effects Mus musculus