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Literature summary for 4.1.1.17 extracted from

  • Docimo, T.; Reichelt, M.; Schneider, B.; Kai, M.; Kunert, G.; Gershenzon, J.; DAuria, J.C.
    The first step in the biosynthesis of cocaine in Erythroxylum coca: the characterization of arginine and ornithine decarboxylases (2012), Plant Mol. Biol., 78, 599-615.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Erythroxylum coca

Inhibitors

Inhibitors Comment Organism Structure
2-(difluoromethyl)ornithine complete inhibition Erythroxylum coca

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.395
-
L-ornithine pH 8.0, 22°C Erythroxylum coca

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44522
-
x * 44522, calculated Erythroxylum coca

Organism

Organism UniProt Comment Textmining
Erythroxylum coca G4XUJ8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bud transcript levels are highest in buds and rolled leaves and lower in other organs Erythroxylum coca
-
leaf transcript levels are highest in buds and rolled leaves and lower in other organs Erythroxylum coca
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Erythroxylum coca putrescine + CO2
-
?
additional information no substrates: lysine, arginine Erythroxylum coca ?
-
?

Subunits

Subunits Comment Organism
? x * 44522, calculated Erythroxylum coca

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.18
-
L-ornithine pH 8.0, 22°C Erythroxylum coca

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Erythroxylum coca

General Information

General Information Comment Organism
physiological function enzyme can complement ornithine decarboxylase mutant in Saccharomyces cerevisiae Erythroxylum coca

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.465
-
L-ornithine pH 8.0, 22°C Erythroxylum coca