Literature summary for 4.1.1.17 extracted from

Illingworth, C.; Michael, A.J.
Plant ornithine decarboxylase is not post-transcriptionally feedback regulated by polyamines but can interact with a cytosolic ribosomal protein S15 polypeptide (2012), Amino Acids, 42, 519-527.

Search for more literature for 4.1.1.17

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Saccharomyces cerevisiae	Arabidopsis thaliana

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(difluoromethyl)-L-ornithine	ODC suicide inhibitor, 5 mM alpha-difluromethylornithine reduces ODC activity by 45fold	Arabidopsis thaliana
antizyme	non-competitive protein inhibitor of ODC. Binding of antizyme to an ODC monomer subunit results in enzymatic inhibition, rapid ubiquitin-independent degradation of ODC by the 26S proteasome and recycling of antizyme	Arabidopsis thaliana
additional information	Arabidopsis S15 ribosomal protein does not inhibit the enzymatic activity of the plant ODC	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	cultivar Columbia, Landsberg erecta	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-ornithine	-	Arabidopsis thaliana	putrescine + CO2	-	?
additional information	the Arabidopsis rpS15 polypeptide interacts specifically with plant ODC	Arabidopsis thaliana	?	-	?

Synonyms

Synonyms	Comment	Organism
ODC	-	Arabidopsis thaliana

Expression

Organism	Comment	Expression
Arabidopsis thaliana	plant cells grown in liquid culture do not exhibit any substantial post-transcriptional, polyamine-responsive feedback regulation of ODC	additional information
Arabidopsis thaliana	methyl jasmonate increases ODC activity by 6.3-7fold and increases ODC mRNA accumulation to an even greater extent. The presence of either putrescine, agmatine, spermidine or spermine simultaneously with methyl jasmonate has little effect on the increased ODC mRNA level and ODC activities caused by the presence of methyl jasmonate	up

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Release 2023.1 (January 2023)