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Literature summary for 4.1.1.17 extracted from

  • Correa-Basurto, J.; Rodríguez-Paez, L.; Aguiar-Moreno, E.; Lopez-Sanchez, P.; Espinoza-Fonseca, L.; Wong, C.; Trujillo-Ferrara, J.
    Computational and experimental evaluation of ornithine derivatives as ornithine decarboxylase inhibitors (2009), Med. Chem. Res., 18, 20-30.
No PubMed abstract available
Search for more literature for 4.1.1.17

Inhibitors

Inhibitors Comment Organism Structure
(2R)-2-amino-4-[(2-oxopropyl)amino]butanoic acid
-
 Rattus norvegicus
(2R)-2-amino-5-[(2-oxopropyl)amino]pentanoic acid
-
 Rattus norvegicus
(2S)-5-amino-2-hydrazinylpentanoic acid
-
 Rattus norvegicus
difluoro-methyl-ornithine
-
 Rattus norvegicus
monofluoro-methyl-ornithine
-
 Rattus norvegicus
N-delta-chloroacetyl-L-ornithine
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
 L-ornithine
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Rattus norvegicus
-
 putrescine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Rattus norvegicus putrescine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ODC
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00046
-
 (2S)-5-amino-2-hydrazinylpentanoic acid
-
 Rattus norvegicus