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Literature summary for 4.1.1.17 extracted from

  • Hsu, P.C.; Hung, H.C.; Liao, Y.F.; Liu, C.C.; Tsay, G.J.; Liu, G.Y.
    Ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells (2008), Leuk. Res., 32, 1530-1540.
    View publication on PubMed
Search for more literature for 4.1.1.17

Protein Variants

Protein Variants Comment Organism
K69A/C360A site-directed mutagenesis, a dominant negative mutant Homo sapiens
additional information overexpression of ODC prevents apoptosis induced by tumor necrosis factor-alpha and methotrexate. ODC overexpressing cells seem to overcome the G1 arrest and G2/M arrest, caused by VP-16 and TAX, respectively, and keep on the cell cycle rolling. Overexpression of ODC increases the expression of Cyclin A, D, E and Cdk4 and the enzyme activity of Cdk1 and Cdk2 after the treatment of VP-16 and TAX, respectively Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Homo sapiens ODC is the rate-limiting enzyme of the polyamine biosynthetic pathway, and plays an important role in cell cycle, tumor promotion and anti-apoptosis putrescine + CO2
-
 ?
additional information Homo sapiens ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells. With higher ODC activity, cells are resistant to the cancer chemotherapeutic drugs-induced apoptosis and keep on the cell cycle rolling with the significant interference in G1/S arrest caused by VP-16 and G2/M arrest by TAX, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene odc
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Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-
promyelocytic leukemia cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Homo sapiens putrescine + CO2
-
 ?
L-ornithine ODC is the rate-limiting enzyme of the polyamine biosynthetic pathway, and plays an important role in cell cycle, tumor promotion and anti-apoptosis Homo sapiens putrescine + CO2
-
 ?
additional information ornithine decarboxylase attenuates leukemic chemotherapy drugs-induced cell apoptosis and arrest in human promyelocytic HL-60 cells. With higher ODC activity, cells are resistant to the cancer chemotherapeutic drugs-induced apoptosis and keep on the cell cycle rolling with the significant interference in G1/S arrest caused by VP-16 and G2/M arrest by TAX, overview Homo sapiens ?
-
 ?