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Literature summary for 4.1.1.17 extracted from
- Structural requirements for novel coenzyme-substrate derivatives to inhibit intracellular ornithine decarboxylase and cell proliferation (2008), FASEB J., 23, 565-574.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the enzyme is a potential anticancer target for inhibitor development | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-DL-difluoromethylornithine | a medically used, irreversible inhibitor of ODC | Homo sapiens |  |
| methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]-1-methylhistidinate | - |
Homo sapiens | |
| methyl N-[[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl]histidinate | - |
Homo sapiens | |
| methyl N5-(tert-butoxycarbonyl)-N2-{[3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl]methyl}-L-ornithinate | - |
Homo sapiens | |
| additional information | no inhibition by phosphopyridoxyl-pyridine-D-Ala and BOC-protected phosphopyridoxyl-alpha,gamma-diaminobutyric acid, coenzyme derivative inhibitor development, molecular modeling and inhibition mechanism, binding model of the phosphopyridoxyl conjugates in the active site of hODC, overview | Homo sapiens | |
| phosphopyridoxyl-histidine | - |
Homo sapiens | |
| phosphopyridoxyl-L-tryptophan methyl ester | - |
Homo sapiens | |
| phosphopyridoxyl-phenylalanine | - |
Homo sapiens | |
| pyridoxyl-L-phenylalanine methyl ester | - |
Homo sapiens | |
| pyridoxyl-L-tryptophan methyl ester | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| intracellular | - |
Homo sapiens | 5622 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | Homo sapiens | - |
putrescine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P11926 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| glioma cell | - |
Homo sapiens | - |
| LN-229 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | - |
Homo sapiens | putrescine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ODC | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | dependent on | Homo sapiens | |
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Release 2023.1 (January 2023)
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