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Literature summary for 4.1.1.17 extracted from

  • Koomoa, D.L.; Yco, L.P.; Borsics, T.; Wallick, C.J.; Bachmann, A.S.
    Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma (2008), Cancer Res., 68, 9825-9831.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.17

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylornithine i.e. DFMO, ODC inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma, inhibition of ODC by DFMO promotes cell survival by inducing the phosphorylation of Akt/PKB at residue Ser473 and glycogen synthase kinase-3B at Ser9, DFMO also induces the phosphorylation of p27Kip1 at residues Ser10, involved in nuclear export, and Thr198, involved in protein stabilization, but not Thr187, involved in proteasomal degradation,inhibition mechanism, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Homo sapiens ODC is a key enzyme in mammalian polyamine biosynthesis that is up-regulated in various types of cancer putrescine + CO2
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 ?
additional information Homo sapiens ODC inhibition by alpha-difluoromethylornithine, and following polyamine depletion, activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
LAN-1 cell a human NB cell line Homo sapiens
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neuroblastoma cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
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 Homo sapiens putrescine + CO2
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 ?
L-ornithine ODC is a key enzyme in mammalian polyamine biosynthesis that is up-regulated in various types of cancer Homo sapiens putrescine + CO2
-
 ?
additional information ODC inhibition by alpha-difluoromethylornithine, and following polyamine depletion, activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
ODC
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 Homo sapiens