Application | Comment | Organism |
---|---|---|
medicine | ODC inhibition enhances the anti-tumor effect of antiangiogenesis therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-difluoromethylornithine | i.e. DFMO or eflornithine | Homo sapiens | |
alpha-difluoromethylornithine | i.e. DFMO or eflornithine | Rattus norvegicus | |
additional information | hypoxia deminishes ODC expression, ODC inhibition enhances the anti-tumor effect of antiangiogenesis therapy | Homo sapiens | |
additional information | hypoxia deminishes ODC expression | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | Homo sapiens | key enzyme of polyamine biosynthesis, essential role of the polyamines in cancer cell adaptation to hypoxic stress, effects of hypoxia on the polyamine system in cancer cells, overview. Compensatory up-regulation of polyamine transport on inhibition of ODC | putrescine + CO2 | - |
? | |
L-ornithine | Rattus norvegicus | key enzyme of polyamine biosynthesis, essential role of the polyamines in cancer cell adaptation to hypoxic stress, effects of hypoxia on the polyamine system in cancer cells, overview. Compensatory up-regulation of polyamine transport on inhibition of ODC | putrescine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell | - |
Rattus norvegicus | - |
HeLa cell | a cervix cancer cell line | Homo sapiens | - |
LS174T cell | a colon carcinoma cell line | Homo sapiens | - |
MCF-7 cell | a breast cancer cell line | Homo sapiens | - |
PC-3 cell | prostate cancer cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | - |
Homo sapiens | putrescine + CO2 | - |
? | |
L-ornithine | - |
Rattus norvegicus | putrescine + CO2 | - |
? | |
L-ornithine | key enzyme of polyamine biosynthesis, essential role of the polyamines in cancer cell adaptation to hypoxic stress, effects of hypoxia on the polyamine system in cancer cells, overview. Compensatory up-regulation of polyamine transport on inhibition of ODC | Homo sapiens | putrescine + CO2 | - |
? | |
L-ornithine | key enzyme of polyamine biosynthesis, essential role of the polyamines in cancer cell adaptation to hypoxic stress, effects of hypoxia on the polyamine system in cancer cells, overview. Compensatory up-regulation of polyamine transport on inhibition of ODC | Rattus norvegicus | putrescine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODC | - |
Homo sapiens |
ODC | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens | |
pyridoxal 5'-phosphate | - |
Rattus norvegicus |