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Literature summary for 4.1.1.17 extracted from

  • Deng, W.; Jiang, X.; Mei, Y.; Sun, J.; Ma, R.; Liu, X.; Sun, H.; Tian, H.; Sun, X.
    Role of ornithine decarboxylase in breast cancer (2008), Acta Biochim. Biophys. Sin., 40, 235-243.
    View publication on PubMed
Search for more literature for 4.1.1.17

Application

Application Comment Organism
drug development the ODC gene might act as a prognostic factor for breast cancer and it could be a promising therapeutic target for cancer research Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transfection of breast cancer cells with an adenoviral vector carrying antisense ODC, rAd-ODC/Ex3as, expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information positive correlation between the level of ODC mRNA and the staging of tumors in MDA-MB-231 cells expressing an ODC antisense construct. Gene transfection of rAd-ODC/Ex3as markedly down-regulates expression of ODC and cyclin D1, resulting in suppression of proliferation and cell cycle arrest at G0-G1 phase, and the inhibition of colony formation, an anchorage-independent growth pattern, and the migratory ability of MDA-MB-231 cells. rAd-ODC/Ex3as also markedly reduces the concentration of putrescine, but not spermidine or spermine, in MDA-MB-231 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Homo sapiens ODC is the rate-limiting enzyme in polyamine biosynthesis that decarboxylates ornithine to putrescine putrescine + CO2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast epithelial cells Homo sapiens
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breast cancer cell
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 Homo sapiens
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BT-474 cell breast cancer cell line Homo sapiens
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MCF-10A cell breast epithelial cell line Homo sapiens
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MCF-7 cell breast cancer cell line Homo sapiens
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MDA-MB-231 cell breast cancer cell line Homo sapiens
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MDA-MB-435 cell breast cancer cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
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 Homo sapiens putrescine + CO2
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 ?
L-ornithine ODC is the rate-limiting enzyme in polyamine biosynthesis that decarboxylates ornithine to putrescine Homo sapiens putrescine + CO2
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 ?

Synonyms

Synonyms Comment Organism
ODC
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 Homo sapiens