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Literature summary for 4.1.1.17 extracted from
- Sexual dimorphism of ornithine decarboxylase in the mouse adrenal: influence of polyamine deprivation on catecholamine and corticoid levels (2007), Am. J. Physiol. Endocrinol. Metab., 292, E1010-E1017.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-difluoromethylornithine | a suicide inhibitor of ODC | Mus musculus |  |
| testosterone | 29% decrease in activity in female mice, more important chnage in female compared to male mice, overview | Mus musculus | |
| testosterone propionate | decreases ODC activity by 56% in adrenal gland of castrated male mice, not in female mice | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | Mus musculus | the enzyme is involved in polyamine biosynthesis, and is regulated mainly by posttranscriptional mechanisms, influence of polyamine deprivation on catecholamine and corticoid levels, sexual dimorphism of the enzyme in the adrenal gland resulting in sex-related differences in prevalent diseases and stress responses, overview | putrescine + CO2 | - |
? | |
| additional information | Mus musculus | circadian variations in ODC activity in female and male mice, influence of sex hormones, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P00860 | ODC1; Swiss CD1 mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | sexual dimorphism of the enzyme in the adrenal | Mus musculus | - |
| additional information | adrenal weight, ODC activity, immunoreactivity, and corticosterone and aldosterone secretion are higher in female than in male mice, while orchidectomy brings the male parameters closer to the values of females, overview | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
circadian variations in ODC activity in female and male mice, overview | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | - |
Mus musculus | putrescine + CO2 | - |
? | |
| L-ornithine | the enzyme is involved in polyamine biosynthesis, and is regulated mainly by posttranscriptional mechanisms, influence of polyamine deprivation on catecholamine and corticoid levels, sexual dimorphism of the enzyme in the adrenal gland resulting in sex-related differences in prevalent diseases and stress responses, overview | Mus musculus | putrescine + CO2 | - |
? | |
| additional information | circadian variations in ODC activity in female and male mice, influence of sex hormones, overview | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ODC | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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