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Literature summary for 4.1.1.17 extracted from
- Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth (2007), Acta Biochim. Biophys. Sin., 39, 423-430.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | ODC can be useful in gene diagnosis and gene therapy of cancers, since some chemotherapeutic agents aim at reducing ODC expression and show inhibitory effects on cancer cell growth | Homo sapiens |
| medicine | ODC can be useful in gene diagnosis and gene therapy of cancers, since some chemotherapeutic agents aim at reducing ODC expression and show inhibitory effects on cancer cell growth | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene ODC, adenovirus-mediated expression, the virus containing the cytomegalovirus promoter and the green fluorescent protein gene, of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase in A-549 cells, quantitative and tissue expression analysis, G1 arrest rate, overview | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase in A-549 cells injected into BALB/c nude male mice inhibits lung cancer cell growth in the mouse tumor, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | some chemotherapeutic agents aim at reducing ODC expression and show inhibitory effects on cancer cell growth, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | Homo sapiens | the enzyme is involved in polyamine biosynthesis, the enzyme is increased in cancer cells | putrescine + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | lung cancer cell line | Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| additional information | the enzyme is increased in cancer cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-ornithine | - |
Homo sapiens | putrescine + CO2 | - |
? | |
| L-ornithine | the enzyme is involved in polyamine biosynthesis, the enzyme is increased in cancer cells | Homo sapiens | putrescine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ODC | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
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