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Literature summary for 4.1.1.17 extracted from

  • Myers, D.P.; Jackson, L.K.; Ipe, V.G.; Murphy, G.E.; Phillips, M.A.
    Long-range interactions in the dimer interface of ornithine decarboxylase are important for enzyme function (2001), Biochemistry, 40, 13230-13236.
    View publication on PubMed
Search for more literature for 4.1.1.17

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma brucei

Protein Variants

Protein Variants Comment Organism
C114A 59% of wild-type activity Trypanosoma brucei
C360A 3% of wild-type activity Trypanosoma brucei
D137A 103% of wild-type activity Trypanosoma brucei
D361A 33% of wild-type activity Trypanosoma brucei
E36A 59% of wild-type activity Trypanosoma brucei
F170A 53% of wild-type activity Trypanosoma brucei
F397A 0.3% of wild-type activity Trypanosoma brucei
F400A 0.15% of wild-type activity Trypanosoma brucei
I291A 20% of wild-type activity Trypanosoma brucei
K141A 3% of wild-type activity Trypanosoma brucei
K169A 1% of wild-type activity Trypanosoma brucei
K294A 8% of wild-type activity Trypanosoma brucei
L330A 29% of wild-type activity Trypanosoma brucei
L363A 36% of wild-type activity Trypanosoma brucei
N398A 3% of wild-type activity Trypanosoma brucei
Q116A 67% of wild-type activity Trypanosoma brucei
S395A 6% of wild-type activity Trypanosoma brucei
T93A 61% of wild-type activity Trypanosoma brucei
V392A 10% of wild-type activity Trypanosoma brucei
W356A 17% of wild-type activity Trypanosoma brucei
Y317A 10% of wild-type activity Trypanosoma brucei
Y323A 0.4% of wild-type activity Trypanosoma brucei
Y331A 64% of wild-type activity Trypanosoma brucei
Y389A no activity Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.49
-
 L-ornithine
-
 Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Trypanosoma brucei
-
 putrescine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei P07805
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant ODC Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Trypanosoma brucei putrescine + CO2
-
 ?

Subunits

Subunits Comment Organism
dimer ODC is an obligate homodimer Trypanosoma brucei

Synonyms

Synonyms Comment Organism
ODC
-
 Trypanosoma brucei

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
9.4
-
 L-ornithine
-
 Trypanosoma brucei

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Trypanosoma brucei