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Literature summary for 4.1.1.17 extracted from
- Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by a alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites (1992), J. Biol. Chem., 267, 150-158.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Mus musculus |
| wild type and mutant enzymes C360A, K69A, and C70S | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-DL-difluoromethylornithine | irreversibel; mechanism of irreversible inactivation | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Orn | - |
Mus musculus | Putrescine + CO2 | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | bound to Lys69 | Mus musculus | |
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