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Literature summary for 4.1.1.15 extracted from
- Glutamate decarboxylase of the parasitic arthropods Ctenocephalides felis and Rhipicephalus microplus: gene identification, cloning, expression, assay development, identification of inhibitors by high throughput screening and comparison with the orthologs (2013), Insect Biochem. Mol. Biol., 43, 162-177.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene gad, DNA and amino acid sequence determination and analysis, cloning in Escherichia coli strain DH5alpha, expression of His-tagged enzyme in Escherichia coli strain M15 | Ctenocephalides felis |
| gene gad, DNA and amino acid sequence determination and analysis, cloning in Escherichia coli strain DH5alpha, expression of His-tagged enzyme in Escherichia coli strain M15 | Rhipicephalus microplus |
| gene gad, expression of enzyme as maltose-bindig protein fusion protein in Escherichia coli strain TB1 | Drosophila melanogaster |
| gene gad65, expression of the enzyme as maltose-bindig protein fusion protein in Escherichia coli strain TB1 | Mus musculus |
| gene gad67, expression of the isozyme as maltose-bindig protein fusion protein in Escherichia coli strain TB1 | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine | - |
Ctenocephalides felis |  |
| (4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine | - |
Drosophila melanogaster | |
| (4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine | - |
Mus musculus | |
| (4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine | - |
Rhipicephalus microplus | |
| (5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one | - |
Ctenocephalides felis | |
| (5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one | - |
Drosophila melanogaster | |
| (5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one | - |
Mus musculus | |
| (5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one | - |
Rhipicephalus microplus | |
| 1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside | - |
Ctenocephalides felis | |
| 1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside | - |
Drosophila melanogaster | |
| 1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside | - |
Mus musculus | |
| 1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside | - |
Rhipicephalus microplus | |
| 1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde | - |
Ctenocephalides felis | |
| 1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde | - |
Drosophila melanogaster | |
| 1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde | - |
Mus musculus | |
| 1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde | - |
Rhipicephalus microplus | |
| 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one | - |
Ctenocephalides felis | |
| 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one | - |
Drosophila melanogaster | |
| 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one | - |
Mus musculus | |
| 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one | - |
Rhipicephalus microplus | |
| 2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol | - |
Ctenocephalides felis | |
| 2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol | - |
Drosophila melanogaster | |
| 2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol | - |
Mus musculus | |
| 2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol | - |
Rhipicephalus microplus | |
| 2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione | - |
Ctenocephalides felis | |
| 2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione | - |
Drosophila melanogaster | |
| 2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione | - |
Mus musculus | |
| 2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione | - |
Rhipicephalus microplus | |
| 2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide | - |
Ctenocephalides felis | |
| 2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide | - |
Drosophila melanogaster | |
| 2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide | - |
Mus musculus | |
| 2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide | - |
Rhipicephalus microplus | |
| 2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione | - |
Ctenocephalides felis | |
| 2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione | - |
Drosophila melanogaster | |
| 2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione | - |
Mus musculus | |
| 2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione | - |
Rhipicephalus microplus | |
| 2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one | - |
Ctenocephalides felis | |
| 2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one | - |
Drosophila melanogaster | |
| 2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one | - |
Mus musculus | |
| 2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one | - |
Rhipicephalus microplus | |
| 2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid | - |
Ctenocephalides felis | |
| 2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid | - |
Drosophila melanogaster | |
| 2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid | - |
Mus musculus | |
| 2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid | - |
Rhipicephalus microplus | |
| 2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile | - |
Ctenocephalides felis | |
| 2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile | - |
Drosophila melanogaster | |
| 2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile | - |
Mus musculus | |
| 2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile | - |
Rhipicephalus microplus | |
| 3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole) | - |
Ctenocephalides felis | |
| 3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole) | - |
Drosophila melanogaster | |
| 3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole) | - |
Mus musculus | |
| 3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole) | - |
Rhipicephalus microplus | |
| 3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid | - |
Ctenocephalides felis | |
| 3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid | - |
Drosophila melanogaster | |
| 3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid | - |
Mus musculus | |
| 3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid | - |
Rhipicephalus microplus | |
| 3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | - |
Ctenocephalides felis | |
| 3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | - |
Drosophila melanogaster | |
| 3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | - |
Mus musculus | |
| 3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | - |
Rhipicephalus microplus | |
| 3-[(E)-(4-methoxybenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | - |
Ctenocephalides felis | |
| 3-[(E)-(4-methoxybenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | - |
Drosophila melanogaster | |
| 3-[(E)-(4-methoxybenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | - |
Mus musculus | |
| 3-[(E)-(4-methoxybenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | - |
Rhipicephalus microplus | |
| 4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one] | - |
Ctenocephalides felis | |
| 4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one] | - |
Drosophila melanogaster | |
| 4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one] | - |
Mus musculus | |
| 4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one] | - |
Rhipicephalus microplus | |
| 4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one) | - |
Ctenocephalides felis | |
| 4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one) | - |
Drosophila melanogaster | |
| 4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one) | - |
Mus musculus | |
| 4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one) | - |
Rhipicephalus microplus | |
| 4-(morpholin-4-yl)naphthalene-1,2-dione | - |
Ctenocephalides felis | |
| 4-(morpholin-4-yl)naphthalene-1,2-dione | - |
Drosophila melanogaster | |
| 4-(morpholin-4-yl)naphthalene-1,2-dione | - |
Mus musculus | |
| 4-(morpholin-4-yl)naphthalene-1,2-dione | - |
Rhipicephalus microplus | |
| 4-(piperidin-1-yl)naphthalene-1,2-dione | - |
Ctenocephalides felis | |
| 4-(piperidin-1-yl)naphthalene-1,2-dione | - |
Drosophila melanogaster | |
| 4-(piperidin-1-yl)naphthalene-1,2-dione | - |
Mus musculus | |
| 4-(piperidin-1-yl)naphthalene-1,2-dione | - |
Rhipicephalus microplus | |
| 4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole | - |
Ctenocephalides felis | |
| 4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole | - |
Drosophila melanogaster | |
| 4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole | - |
Mus musculus | |
| 4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole | - |
Rhipicephalus microplus | |
| 4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole | - |
Ctenocephalides felis | |
| 4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole | - |
Drosophila melanogaster | |
| 4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole | - |
Mus musculus | |
| 4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole | - |
Rhipicephalus microplus | |
| 4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid | - |
Ctenocephalides felis | |
| 4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid | - |
Drosophila melanogaster | |
| 4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid | - |
Mus musculus | |
| 4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid | - |
Rhipicephalus microplus | |
| 5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol | - |
Ctenocephalides felis | |
| 5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol | - |
Drosophila melanogaster | |
| 5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol | - |
Mus musculus | |
| 5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol | - |
Rhipicephalus microplus | |
| 5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione | - |
Ctenocephalides felis | |
| 5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione | - |
Drosophila melanogaster | |
| 5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione | - |
Mus musculus | |
| 5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione | - |
Rhipicephalus microplus | |
| 5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one | - |
Ctenocephalides felis | |
| 5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one | - |
Drosophila melanogaster | |
| 5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one | - |
Mus musculus | |
| 5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one | - |
Rhipicephalus microplus | |
| 5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | - |
Ctenocephalides felis | |
| 5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | - |
Drosophila melanogaster | |
| 5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | - |
Mus musculus | |
| 5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | - |
Rhipicephalus microplus | |
| 6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium | - |
Ctenocephalides felis | |
| 6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium | - |
Drosophila melanogaster | |
| 6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium | - |
Mus musculus | |
| 6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium | - |
Rhipicephalus microplus | |
| 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one | - |
Ctenocephalides felis | |
| 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one | - |
Drosophila melanogaster | |
| 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one | - |
Mus musculus | |
| 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one | - |
Rhipicephalus microplus | |
| biphenyl-3,3'-dicarbaldehyde | - |
Ctenocephalides felis | |
| biphenyl-3,3'-dicarbaldehyde | - |
Drosophila melanogaster | |
| biphenyl-3,3'-dicarbaldehyde | - |
Mus musculus | |
| biphenyl-3,3'-dicarbaldehyde | - |
Rhipicephalus microplus | |
| carboxymethoxylamine | - |
Ctenocephalides felis | |
| carboxymethoxylamine | - |
Drosophila melanogaster | |
| carboxymethoxylamine | - |
Mus musculus | |
| carboxymethoxylamine | - |
Rhipicephalus microplus | |
| methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate | - |
Ctenocephalides felis | |
| methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate | - |
Drosophila melanogaster | |
| methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate | - |
Mus musculus | |
| methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate | - |
Rhipicephalus microplus | |
| methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate | - |
Ctenocephalides felis | |
| methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate | - |
Drosophila melanogaster | |
| methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate | - |
Mus musculus | |
| methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate | - |
Rhipicephalus microplus | |
| additional information | inhibitor screening, overview | Ctenocephalides felis | |
| additional information | inhibitor screening, overview | Drosophila melanogaster | |
| additional information | inhibitor screening, overview; inhibitor screening, overview | Mus musculus | |
| additional information | inhibitor screening, overview | Rhipicephalus microplus | |
| N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide | - |
Ctenocephalides felis | |
| N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide | - |
Drosophila melanogaster | |
| N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide | - |
Mus musculus | |
| N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide | - |
Rhipicephalus microplus | |
| N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | - |
Ctenocephalides felis | |
| N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | - |
Drosophila melanogaster | |
| N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | - |
Mus musculus | |
| N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | - |
Rhipicephalus microplus | |
| N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | - |
Ctenocephalides felis | |
| N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | - |
Drosophila melanogaster | |
| N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | - |
Mus musculus | |
| N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | - |
Rhipicephalus microplus | |
| naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione | - |
Ctenocephalides felis | |
| naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione | - |
Drosophila melanogaster | |
| naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione | - |
Mus musculus | |
| naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione | - |
Rhipicephalus microplus | |
| [(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid | - |
Ctenocephalides felis | |
| [(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid | - |
Drosophila melanogaster | |
| [(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid | - |
Mus musculus | |
| [(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid | - |
Rhipicephalus microplus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics | Mus musculus | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Ctenocephalides felis | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Rhipicephalus microplus | |
| additional information | - |
additional information | Michaelis-Menten kinetics | Drosophila melanogaster | |
| 5.4 | - |
L-glutamate | pH 8.0, 37°C, recombinant enzyme | Mus musculus | |
| 6.1 | - |
L-glutamate | pH 8.0, 37°C, recombinant enzyme | Mus musculus | |
| 8.8 | - |
L-glutamate | pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | |
| 10.1 | - |
L-glutamate | pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate | Mus musculus | - |
4-aminobutanoate + CO2 | - |
? | |
| L-glutamate | Ctenocephalides felis | - |
4-aminobutanoate + CO2 | - |
? | |
| L-glutamate | Rhipicephalus microplus | - |
4-aminobutanoate + CO2 | - |
? | |
| L-glutamate | Drosophila melanogaster | - |
4-aminobutanoate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ctenocephalides felis | K7WYY0 | gene gad | - |
| Drosophila melanogaster | P20228 | gene gad | - |
| Mus musculus | P48318 | isozyme Gad67; gene gad67 encoding isozyme Gad67 | - |
| Mus musculus | P48320 | isozyme Gad65; gene gad65 encoding isozyme Gad65 | - |
| Rhipicephalus microplus | K7XPX5 | gene gad | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate | - |
Mus musculus | 4-aminobutanoate + CO2 | - |
? | |
| L-glutamate | - |
Ctenocephalides felis | 4-aminobutanoate + CO2 | - |
? | |
| L-glutamate | - |
Rhipicephalus microplus | 4-aminobutanoate + CO2 | - |
? | |
| L-glutamate | - |
Drosophila melanogaster | 4-aminobutanoate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAD | - |
Ctenocephalides felis |
| GAD | - |
Rhipicephalus microplus |
| GAD1 | - |
Drosophila melanogaster |
| Gad56 | - |
Mus musculus |
| GAD67 | - |
Mus musculus |
| L-glutamate 1-carboxylyase | - |
Mus musculus |
| L-glutamate 1-carboxylyase | - |
Ctenocephalides felis |
| L-glutamate 1-carboxylyase | - |
Rhipicephalus microplus |
| L-glutamate 1-carboxylyase | - |
Drosophila melanogaster |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Ctenocephalides felis |
| 37 | - |
assay at | Rhipicephalus microplus |
| 37 | - |
assay at | Drosophila melanogaster |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 8.5 | assay at | Mus musculus |
| 8 | 8.5 | assay at | Ctenocephalides felis |
| 8 | 8.5 | assay at | Rhipicephalus microplus |
| 8 | 8.5 | assay at | Drosophila melanogaster |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole) | |
| 0.0004 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | carboxymethoxylamine | |
| 0.0004 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole) | |
| 0.0005 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | carboxymethoxylamine | |
| 0.001 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | carboxymethoxylamine | |
| 0.001 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | carboxymethoxylamine | |
| 0.001 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate | |
| 0.001 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | |
| 0.0011 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | |
| 0.0011 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | |
| 0.0012 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | |
| 0.0013 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | |
| 0.0014 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate | |
| 0.0015 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate | |
| 0.0017 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate | |
| 0.0018 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | |
| 0.002 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one | |
| 0.002 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one | |
| 0.002 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one | |
| 0.002 | 4 | pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one | |
| 0.002 | 4 | pH 8.0, 37°C, recombinant enzyme | Mus musculus | methyl 2-amino-3-oxo-3H-phenothiazine-1-carboxylate | |
| 0.0021 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium | |
| 0.0022 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium | |
| 0.0022 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | |
| 0.0022 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | N-[4,7-dioxo-6-(phenylamino)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | |
| 0.0023 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium | |
| 0.0023 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | |
| 0.0026 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid | |
| 0.0029 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium | |
| 0.0029 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4-(morpholin-4-yl)naphthalene-1,2-dione | |
| 0.003 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 4-(piperidin-1-yl)naphthalene-1,2-dione | |
| 0.003 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4-(piperidin-1-yl)naphthalene-1,2-dione | |
| 0.003 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 4-(morpholin-4-yl)naphthalene-1,2-dione | |
| 0.0033 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | (5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one | |
| 0.0033 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | (5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one | |
| 0.0033 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol | |
| 0.0034 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole | |
| 0.0034 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 4-(morpholin-4-yl)naphthalene-1,2-dione | |
| 0.0037 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione | |
| 0.0037 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | (5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one | |
| 0.0037 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol | |
| 0.0038 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside | |
| 0.0038 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 4-(piperidin-1-yl)naphthalene-1,2-dione | |
| 0.0039 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione | |
| 0.0039 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 4-(morpholin-4-yl)naphthalene-1,2-dione | |
| 0.004 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside | |
| 0.004 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside | |
| 0.0041 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione | |
| 0.0042 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione | |
| 0.0044 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | N-[4,7-dioxo-6-(piperidin-1-yl)-4,7-dihydro-2,1,3-benzoxadiazol-5-yl]acetamide | |
| 0.0045 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one | |
| 0.0045 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4-(morpholin-4-yl)naphthalene-1,2-dione | |
| 0.0047 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione | |
| 0.0047 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one | |
| 0.0047 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4-(piperidin-1-yl)naphthalene-1,2-dione | |
| 0.0049 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | biphenyl-3,3'-dicarbaldehyde | |
| 0.005 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate | |
| 0.0051 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol | |
| 0.0052 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide | |
| 0.0053 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | biphenyl-3,3'-dicarbaldehyde | |
| 0.0053 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside | |
| 0.0053 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol | |
| 0.0053 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 4-(piperidin-1-yl)naphthalene-1,2-dione | |
| 0.0055 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole | |
| 0.0055 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde | |
| 0.0056 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one | |
| 0.0057 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 6,11-dioxo-5a,6,11,11a-tetrahydronaphtho[2',3':4,5][1,3]thiazolo[3,2-a]pyridin-12-ium | |
| 0.0057 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | (5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one | |
| 0.0057 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol | |
| 0.0059 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one | |
| 0.006 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate | |
| 0.0062 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate | |
| 0.0062 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | biphenyl-3,3'-dicarbaldehyde | |
| 0.0062 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione | |
| 0.0063 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | biphenyl-3,3'-dicarbaldehyde | |
| 0.0063 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | |
| 0.0063 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one | |
| 0.0064 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid | |
| 0.0064 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | |
| 0.0065 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate | |
| 0.0065 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one | |
| 0.0066 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one | |
| 0.0067 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid | |
| 0.0069 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid | |
| 0.0069 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione | |
| 0.0069 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde | |
| 0.0069 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione | |
| 0.0072 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one] | |
| 0.0073 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione | |
| 0.0073 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione | |
| 0.0075 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one | |
| 0.0076 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide | |
| 0.0076 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde | |
| 0.0077 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole | |
| 0.0077 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione | |
| 0.0079 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | |
| 0.008 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde | |
| 0.0082 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide | |
| 0.0082 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile | |
| 0.0083 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 5,6-dichloro-2,1,3-benzothiadiazole-4,7-diol | |
| 0.0087 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide | |
| 0.0087 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione | |
| 0.0089 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione | |
| 0.0089 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one | |
| 0.0089 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile | |
| 0.0091 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide | |
| 0.01 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one | |
| 0.0104 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione | |
| 0.0104 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 5-[(E)-benzylideneamino]-6-[(2-hydroxyethyl)amino]pyrimidine-2,4(1H,3H)-dione | |
| 0.0105 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide | |
| 0.0108 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-hydroxy-2-(2-hydroxy-6-oxocyclohex-2-en-1-yl)-1H-indene-1,3(2H)-dione | |
| 0.0109 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | |
| 0.0112 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4-[(1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl)sulfanyl]butanoic acid | |
| 0.0112 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione | |
| 0.0115 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione | |
| 0.012 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 1,4-dioxo-1,2,3,4-tetrahydronaphthalen-2-yl 2,3,4-tri-O-acetylpentopyranoside | |
| 0.012 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one] | |
| 0.0122 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 3-[(E)-(2,6-difluorobenzylidene)amino]-2-thioxo-1,3-thiazolidin-4-one | |
| 0.0122 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
| 0.0123 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | (4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine | |
| 0.0125 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | methyl 2-[[(2-methylimidazo[1,2-a]pyridin-3-yl)carbonyl]amino]benzoate | |
| 0.0126 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile | |
| 0.0127 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one | |
| 0.0129 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 5-[(E)-[[1-(2-chlorobenzyl)-1H-indol-3-yl]methylidene]amino]-1,3-dihydro-2H-benzimidazol-2-one | |
| 0.013 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one) | |
| 0.0135 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | (4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine | |
| 0.0138 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one) | |
| 0.0138 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile | |
| 0.0139 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one | |
| 0.014 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 2-thioxo-3-[(E)-(3,3,5-trimethylcyclohexylidene)amino]-1,3-thiazolidin-4-one | |
| 0.014 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 2-[(3-formyl-1H-indol-1-yl)methyl]benzonitrile | |
| 0.0142 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 1-(2-nitrobenzyl)-1H-indole-3-carbaldehyde | |
| 0.0143 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one | |
| 0.0144 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
| 0.0148 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole) | |
| 0.0149 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
| 0.0162 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide | |
| 0.0164 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide | |
| 0.0165 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid | |
| 0.0173 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one) | |
| 0.0188 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one) | |
| 0.0196 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole) | |
| 0.0202 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid | |
| 0.0209 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole | |
| 0.0209 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-(benzylsulfanyl)-3-(morpholin-4-yl)-2,3-dihydronaphthalene-1,4-dione | |
| 0.0211 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole | |
| 0.0212 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 3,3'-(4H-1,2,4-triazole-3,5-diyl)bis(4-nitro-1,2,5-oxadiazole) | |
| 0.0218 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one] | |
| 0.0226 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 4,4'-[(4-hydroxyphenyl)methanediyl]bis(2-heptyl-5-methyl-2,4-dihydro-3H-pyrazol-3-one) | |
| 0.0244 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | [(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid | |
| 0.0257 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | [(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid | |
| 0.0266 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | (4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine | |
| 0.0269 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one] | |
| 0.0274 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | (4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine | |
| 0.0284 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | [(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid | |
| 0.0284 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide | |
| 0.03 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | (4Z,7E)-N,N'-dihydroxy-2,2-dimethyl-5,6-dihydro-2H-benzimidazole-4,7-diimine | |
| 0.0418 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | (5Z)-2-amino-5-(2-nitrobenzylidene)-1,3-thiazol-4(5H)-one | |
| 0.0558 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
| 0.0591 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | naphtho[2',3':4,5]imidazo[1,2-a]pyridine-6,11-dione | |
| 0.0593 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 5-[[5-hydroxy-3-methyl-1-(4-methylphenyl)-1H-pyrazol-4-yl]methylidene]-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | |
| 0.065 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4-nitro-1,6-dihydrobenzo[1,2-d:3,4-d']bis[1,2,3]triazole | |
| 0.0714 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid | |
| 0.0777 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol | |
| 0.0845 | - |
pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid | |
| 0.0912 | - |
pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole | |
| 0.0981 | - |
pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole | |
| 0.099 | - |
pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 4,4'-(phenylmethanediyl)bis[2-(4-chlorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one] | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Mus musculus | 4-nitro-7-[[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl]-2,1,3-benzothiadiazole | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 2,4-bis[2-(4-hydroxyphenyl)propan-2-yl]phenol | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Mus musculus | 3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Ctenocephalides felis | 3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Drosophila melanogaster | 3-[(2E)-2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazinyl]benzoic acid | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Mus musculus | [(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]acetic acid | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 2-chloro-N-[5-([2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl]sulfanyl)-1,3,4-thiadiazol-2-yl]acetamide | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Mus musculus | 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Mus musculus | 2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid | |
| 0.1 | - |
above, pH 8.0, 37°C, recombinant enzyme | Rhipicephalus microplus | 2-[(2-chloro-5-nitrobenzoyl)amino]-5-iodobenzoic acid | |
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Release 2023.1 (January 2023)
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