Literature summary for 4.1.1.15 extracted from

Skorstad, G.; Hestvik, A.L.; Vartdal, F.; Holmoy, T.
Cerebrospinal fluid T cell responses against glutamic acid decarboxylase 65 in patients with stiff person syndrome (2008), J. Autoimmun., 32, 24-32.

Search for more literature for 4.1.1.15

Cloned(Commentary)

Cloned (Comment)	Organism
recombinant expression of isozyme GAD65 using the Spodoptera frugiperda transfection method	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	isozyme GAD 65 in the stiff person syndrome causes GAD65-specific T cells accumulation in the central nervous system driving the intrathecal GAD65 IgG production, T cells from the cerebrospinal fluid, mechanism, overview. GAD65-specific T cells and clonally expanded GAD65-specific B cells coexist intrathecally, where they may collaborate in the synthesis of GAD65 IgG	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	isozyme GAD 65 in the stiff person syndrome causes GAD65-specific T cells accumulation in the central nervous system driving the intrathecal GAD65 IgG production, T cells from the cerebrospinal fluid, mechanism, overview. GAD65-specific T cells and clonally expanded GAD65-specific B cells coexist intrathecally, where they may collaborate in the synthesis of GAD65 IgG	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	mapping of T cell epitopes on GAD65, overview	Homo sapiens

Synonyms

Synonyms	Comment	Organism
GAD65	-	Homo sapiens
Glutamic acid decarboxylase	-	Homo sapiens

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Release 2023.1 (January 2023)