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Literature summary for 4.1.1.15 extracted from

  • Martin, D.L.; Liu, H.; Martin, S.B.; Wu, S.J.
    Structural features and regulatory properties of the brain glutamate decarboxylases (2000), Neurochem. Int., 37, 111-119.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Glu
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Rattus norvegicus 4-Aminobutanoate + CO2
-
?

Subunits

Subunits Comment Organism
dimer dimer-forming interactions are mediated mainly by carboxyl-terminal domain Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate although GAD65 and GAD67 interact differently with pyridoxal 5'-phosphate, their cofactor-binding sites contain the same set of nine putative cofactor-binding residues and has the same basic structural fold. Thus the cofactor-binding differences cannot by attributed to fundamental structural differences between the GADs but must result from subtle modifications of the basic cofactor-binding fold Rattus norvegicus