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Literature summary for 4.1.1.15 extracted from

  • Primo, M.E.; Anton, E.A.; Villanueva, A.L.; Poskus, E.; Ermacora, M.R.
    Engineered variants of human glutamic acid decarboxylase (GAD) and autoantibody epitope recognition (2003), Clin. Immunol., 108, 38-45.
    View publication on PubMed
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Application

Application Comment Organism
medicine the autoantibody profile in a variety of patients with diabetes and thyroid autoimmune diseases is probed by a set of GAD65/67 variants: GAD65, GAD65/67 hybrids spanning residues 1-95, 96-444 and 445-585, deltaGAD65, a truncated GAD65 spanning residues 69-585 and GAD67. DeltaGAD65 and GAD65 detect 137 and 125 positive patients, respectively. The hybrids react with 113 sera and in 3 cases disclosed cryptic epitopes. Eighteen patients react with GAD67, indicating GAD65-GAD67 cross-reactivity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens of the two homolous forms of glutamic acid decarboxylase, GAD65 and GAD67, only GAD65 is a common target of autoimmunity ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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 patients with diabetes and thyroid autoimmune diseases
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information of the two homolous forms of glutamic acid decarboxylase, GAD65 and GAD67, only GAD65 is a common target of autoimmunity Homo sapiens ?
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 ?