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Literature summary for 4.1.1.112 extracted from
- Mitochondrial oxaloacetate decarboxylase from rat liver (1974), Biochim. Biophys. Acta, 347, 168-182.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| p-chloromercuribenzoate | - |
Cavia aperea |  |
| p-chloromercuribenzoate | - |
Oryctolagus cuniculus | |
| p-chloromercuribenzoate | 50% inhibition at 0.5 mM | Rattus norvegicus | |
| Zn2+ | 54% inhibition at 1.5 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.55 | - |
oxaloacetate | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
| cytoplasm | - |
Oryctolagus cuniculus | 5737 | - |
| cytoplasm | - |
Cavia aperea | 5737 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Oryctolagus cuniculus | 5739 | - |
| mitochondrion | - |
Cavia aperea | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| oxaloacetate | Rattus norvegicus | - |
? | - |
? | |
| oxaloacetate | Oryctolagus cuniculus | - |
? | - |
? | |
| oxaloacetate | Cavia aperea | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia aperea | - |
guinea pig | - |
| Oryctolagus cuniculus | - |
rabbit | - |
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Oryctolagus cuniculus | - |
| liver | - |
Cavia aperea | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
| additional information | - |
- |
Oryctolagus cuniculus |
| additional information | - |
- |
Cavia aperea |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Oxaloacetate | - |
Oryctolagus cuniculus | Pyruvate + CO2 | - |
? | |
| Oxaloacetate | - |
Cavia aperea | Pyruvate + CO2 | - |
? | |
| Oxaloacetate | reaction mechanism | Rattus norvegicus | Pyruvate + CO2 | - |
? | |
| oxaloacetate | - |
Rattus norvegicus | ? | - |
? | |
| oxaloacetate | - |
Oryctolagus cuniculus | ? | - |
? | |
| oxaloacetate | - |
Cavia aperea | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
enzyme assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 7.5 | - |
Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.5 | - |
p-chloromercuribenzoate | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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