Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | no activation with the CoA-binding-deficient PanMG76L variant | Salmonella enterica | |
PanM | Salmonella enterica PanM, formerly YhhK, a Gcn5-like N-acetyltransferase, is necessary for pro-PanD maturation, both in vitro and in vivo. PanM-dependent pro-PanD maturation does not involve an acetyl transfer event. CoA binding to PanM is needed for in vivo activity, disruption of CoA binding prevents PanM from interacting with PanD. PanM lacks acetyltransferase activity but functions instead as an acetyl-coenzyme A (CoA) sensor, overview | Salmonella enterica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate | Salmonella enterica | - |
beta-alanine + CO2 | - |
? | |
L-aspartate | Salmonella enterica DM10310 | - |
beta-alanine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica | - |
serovar Typhimurium LT2, gene panD | - |
Salmonella enterica DM10310 | - |
serovar Typhimurium LT2, gene panD | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | PanD is a pyruvoyl enzyme that is synthesized by the cell as an inactive precursor, pro-PanD. Maturation of pro-PanD into PanD occurs via a self-cleavage event at residue Ser25, which forms the catalytic pyruvoyl moiety. Salmonella enterica PanM, a Gcn5-like N-acetyltransferase, is necessary for pro-PanD maturation, both in vitro and in vivo | Salmonella enterica |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate | - |
Salmonella enterica | beta-alanine + CO2 | - |
? | |
L-aspartate | - |
Salmonella enterica DM10310 | beta-alanine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PanD | - |
Salmonella enterica |