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Literature summary for 4.1.1.11 extracted from

  • Saldanha, S.A.; Birch, L.M.; Webb, M.E.; Nabbs, B.K.; von Delft, F.; Smith, A.G.; Abell, C.
    Identification of Tyr58 as the proton donor in the aspartate-alpha-decarboxylase reaction (2001), Chem. Commun. (Camb.), 2001, 1760-1761.
No PubMed abstract available
Search for more literature for 4.1.1.11

Cloned(Commentary)

Cloned (Comment) Organism
panD gene overexpression Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
-
 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
14000
-
 4 * 14000 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-aspartate Escherichia coli involved in the biosynthesis of pantothenate beta-alanine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification an integral pyruvoyl group is formed by an autocatalytic posttranslational modification which cleaves the Gly-24/Ser-25 bond and converts Ser-25 into the pyruvoyl group Escherichia coli

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Escherichia coli

Reaction

Reaction Comment Organism Reaction ID
L-aspartate = beta-alanine + CO2 detailed catalytic mechanism Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-aspartate reaction occurs with retention of configuration, Tyr58 acts as proton donor in the decarboxylation mechanism, the active sites are between subunits, mechanism involves formation of an imine between the amino group of aspartate and an integral pyruvoyl group formed by an autocatalytic posttranslational modification Escherichia coli beta-alanine + CO2
-
 ?
L-aspartate involved in the biosynthesis of pantothenate Escherichia coli beta-alanine + CO2
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 14000 Escherichia coli

Synonyms

Synonyms Comment Organism
ADC
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Escherichia coli