Literature summary for 4.1.1.1 extracted from

Pereira, Y.; Lagniel, G.; Godat, E.; Baudouin-Cornu, P.; Junot, C.; Labarre, J.
Chromate causes sulfur starvation in yeast (2008), Toxicol. Sci., 106, 400-412.

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Activating Compound

Activating Compound	Comment	Organism	Structure
chromate	sulfur starvation and chromate treatment induce the expression of Pdc6, PDC6 mRNA level is increased more than 100fold following chromate treatment with toxic doses (0.005, 0.01, and 0.02 mM) but remains unchanged at the lower dose 0.0025 mM	Saccharomyces cerevisiae
Met32 protein	dependent upon Met32 protein	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	strains S288C, YPH98, and W303-1A	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate	-	Saccharomyces cerevisiae	acetaldehyde + CO2	-	?

Synonyms

Synonyms	Comment	Organism
PDC1	sulfur-rich pyruvate decarboxylase	Saccharomyces cerevisiae
Pdc6	sulfur-poor pyruvate decarboxylase, third minor isozyme of pyruvate decarboxylase	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
thiamine diphosphate	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)