Literature summary for 4.1.1.1 extracted from

Tylicki, A.; Lempicka, A.; Romaniuk-Demonchaux, K.; Czerniecki, J.; Dobrzyn, P.; Strumilo, S.
Effect of oxythiamin on growth rate, survival ability and pyruvate decarboxylase activity in Saccharomyces cerevisiae (2003), J. Basic Microbiol., 43, 522-529.

Search for more literature for 4.1.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	growth on a medium with oxythiamine increases enzyme activity, but may be in response to an earlier inhibition of enzyme leading to an accumulation of pyruvate, which induces the biosynthesis of enzyme apoform	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	growth on a medium with oxythiamine increases enzyme activity, but may be in response to an earlier inhibition of enzyme leading to an accumulation of pyruvate, which induces the biosynthesis of enzyme apoform	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pyruvate	Saccharomyces cerevisiae	key role in the alcoholic fermentation process	acetaldehyde + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	activity in cell extracts grown on different media estimated with and without exogenous thiamine diphosphate	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate	-	Saccharomyces cerevisiae	acetaldehyde + CO2	-	?
pyruvate	key role in the alcoholic fermentation process	Saccharomyces cerevisiae	acetaldehyde + CO2	-	?

Cofactor

Cofactor	Comment	Organism	Structure
thiamine diphosphate	prosthetic group	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)