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Literature summary for 3.9.1.3 extracted from

  • Kamath, V.; Kyathanahalli, C.N.; Jayaram, B.; Syed, I.; Olson, L.K.; Ludwig, K.; Klumpp, S.; Krieglstein, J.; Kowluru, A.
    Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells (2010), Am. J. Physiol. Endocrinol. Metab., 299, E276-E286.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.9.1.3

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
16000
-
 x * 16000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[ATP-citrate lyase]-N-phospho-L-histidine + H2O Rattus norvegicus
-
 [ATP-citrate lyase]-L-histidine + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
INS-1 823/13 cell
-
 Rattus norvegicus
-
pancreatic beta cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[ATP-citrate lyase]-N-phospho-L-histidine + H2O
-
 Rattus norvegicus [ATP-citrate lyase]-L-histidine + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 16000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
PHP
-
 Rattus norvegicus
protein histidine phosphatase
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus long-term exposure (24 h) of INS 832/13 cells or rat islets to high glucose (30 mM) increases the expression of the enzyme. Such increases in enzyme expression are also seen in islets derived from the Zucker diabetic fatty rat compared with islets from the lean control animals up

General Information

General Information Comment Organism
malfunction depletion of the enzyme significantly reduces glucose- and mitochondrial fuel- but not KCl-induced insulin secretion Rattus norvegicus
physiological function the enzyme plays a regulatory role in a G protein-sensitive step involved in nutrient-induced insulin secretion. The enzyme is not involved in metabolic cell viability and cell proliferation Rattus norvegicus