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Literature summary for 3.7.1.4 extracted from

  • Zhou, J.; Chen, Y.; Wang, Y.; Gao, X.; Qu, D.; Liu, C.
    A comparative study on the metabolism of Epimedium koreanum nakai-prenylated flavonoids in rats by an intestinal enzyme (lactase phlorizin hydrolase) and intestinal flora (2014), Molecules, 19, 177-203.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
gluconolactone
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
brush border
-
Rattus norvegicus 5903
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
baohuoside I + H2O Rattus norvegicus
-
?
-
?
baohuoside I + H2O Rattus norvegicus Sprague-Dawley
-
?
-
?
epimedin A + H2O Rattus norvegicus
-
?
-
?
epimedin A + H2O Rattus norvegicus Sprague-Dawley
-
?
-
?
epimedin B + H2O Rattus norvegicus
-
?
-
?
epimedin B + H2O Rattus norvegicus Sprague-Dawley
-
?
-
?
epimedin C + H2O Rattus norvegicus
-
?
-
?
icariin + H2O Rattus norvegicus the metabolic pathways of icariin by rat intestinal flora and enzyme solution are basically the same, including 3-O-rhamnose, 7-O-glucose hydrolysis or dual 3, 7-hydrolysis. Compared to 3-O-rhamnose and dual hydrolysis of 3, 7-, the 7-O-glucose hydrolysis is easier. The yielded metabolites contain M1 (icariside I), M2 (icaritin), and baohuoside I ?
-
?
additional information Rattus norvegicus hydrolysis of prenylated flavonoids from Epimedium sp., Epimedii herba, used for a tranditional chinese medicine tonic, Yinyanghuo. Comparison of hydrolysis rates and substrate specificities of intestinal flora and intestinal enzymes, especially lactase phlorizin hydrolase, with the flavonoid substrates, overview. Flavonoid metabolic rates with rat intestinal enzyme are higher than those with intestinal flora. The intestinal hydrolysis of glycosides by intestinal enzymes is rapid. Even icariin is completely metabolized in 6 h and the epimedin A is totally metabolized in 12 h in incubation with intestinal enzyme ?
-
?
additional information Rattus norvegicus Sprague-Dawley hydrolysis of prenylated flavonoids from Epimedium sp., Epimedii herba, used for a tranditional chinese medicine tonic, Yinyanghuo. Comparison of hydrolysis rates and substrate specificities of intestinal flora and intestinal enzymes, especially lactase phlorizin hydrolase, with the flavonoid substrates, overview. Flavonoid metabolic rates with rat intestinal enzyme are higher than those with intestinal flora. The intestinal hydrolysis of glycosides by intestinal enzymes is rapid. Even icariin is completely metabolized in 6 h and the epimedin A is totally metabolized in 12 h in incubation with intestinal enzyme ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q02401
-
-
Rattus norvegicus Sprague-Dawley Q02401
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
baohuoside I + H2O
-
Rattus norvegicus ?
-
?
baohuoside I + H2O
-
Rattus norvegicus Sprague-Dawley ?
-
?
epimedin A + H2O
-
Rattus norvegicus ?
-
?
epimedin A + H2O
-
Rattus norvegicus Sprague-Dawley ?
-
?
epimedin B + H2O
-
Rattus norvegicus ?
-
?
epimedin B + H2O
-
Rattus norvegicus Sprague-Dawley ?
-
?
epimedin C + H2O
-
Rattus norvegicus ?
-
?
icariin + H2O
-
Rattus norvegicus ?
-
?
icariin + H2O the metabolic pathways of icariin by rat intestinal flora and enzyme solution are basically the same, including 3-O-rhamnose, 7-O-glucose hydrolysis or dual 3, 7-hydrolysis. Compared to 3-O-rhamnose and dual hydrolysis of 3, 7-, the 7-O-glucose hydrolysis is easier. The yielded metabolites contain M1 (icariside I), M2 (icaritin), and baohuoside I Rattus norvegicus ?
-
?
additional information hydrolysis of prenylated flavonoids from Epimedium sp., Epimedii herba, used for a tranditional chinese medicine tonic, Yinyanghuo. Comparison of hydrolysis rates and substrate specificities of intestinal flora and intestinal enzymes, especially lactase phlorizin hydrolase, with the flavonoid substrates, overview. Flavonoid metabolic rates with rat intestinal enzyme are higher than those with intestinal flora. The intestinal hydrolysis of glycosides by intestinal enzymes is rapid. Even icariin is completely metabolized in 6 h and the epimedin A is totally metabolized in 12 h in incubation with intestinal enzyme Rattus norvegicus ?
-
?
additional information the enzyme has two distinct catalytic active sites, one for the hydrolysis of lactose and flavonoid glucosides and another, phlorizin hydrolase, for the hydrolysis of phlorizin and phlorizin-glucosylceramides Rattus norvegicus ?
-
?
additional information hydrolysis of prenylated flavonoids from Epimedium sp., Epimedii herba, used for a tranditional chinese medicine tonic, Yinyanghuo. Comparison of hydrolysis rates and substrate specificities of intestinal flora and intestinal enzymes, especially lactase phlorizin hydrolase, with the flavonoid substrates, overview. Flavonoid metabolic rates with rat intestinal enzyme are higher than those with intestinal flora. The intestinal hydrolysis of glycosides by intestinal enzymes is rapid. Even icariin is completely metabolized in 6 h and the epimedin A is totally metabolized in 12 h in incubation with intestinal enzyme Rattus norvegicus Sprague-Dawley ?
-
?
additional information the enzyme has two distinct catalytic active sites, one for the hydrolysis of lactose and flavonoid glucosides and another, phlorizin hydrolase, for the hydrolysis of phlorizin and phlorizin-glucosylceramides Rattus norvegicus Sprague-Dawley ?
-
?

Synonyms

Synonyms Comment Organism
lactase phlorizin hydrolase
-
Rattus norvegicus
LPH
-
Rattus norvegicus

General Information

General Information Comment Organism
metabolism the enzyme is involved in the metabolic pathway of icariin, epimedin A, B, and C, and f baohuoside I in intestinal flora and enzyme of rats, detailed overview Rattus norvegicus
physiological function the enzyme plays a major role in the deglycosylation of daidzin Rattus norvegicus