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Literature summary for 3.7.1.3 extracted from

  • Koushik, S.V.; Moore III, J.A.; Sundararaju, B.; Phillips, R.S.
    The catalytic mechanism of kynureninase from Pseudomonas fluorescens: Insights from the effects of pH and isotopic substitution on steady-state and pre-steady-state kinetics (1998), Biochemistry, 37, 1376-1382.
    View publication on PubMed

Application

Application Comment Organism
medicine NAD+ biosynthesis Pseudomonas fluorescens
medicine tryptophan metabolism Pseudomonas fluorescens

Inhibitors

Inhibitors Comment Organism Structure
(4S)-dihydro-L-kynurenine competitive inhibitor Pseudomonas fluorescens
anthranilic acid
-
Pseudomonas fluorescens
S-(2-aminophenyl)-L-cysteine S,S-dioxide
-
Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-hydroxy-L-kynurenine + H2O Pseudomonas fluorescens
-
3-hydroxyanthranilate + L-Ala
-
?
L-alanine + pyridoxal 5'-phosphate Pseudomonas fluorescens
-
pyruvate + pyridoxamine 5'-phosphate
-
?
L-kynurenine + H2O Pseudomonas fluorescens
-
anthranilate + L-alanine
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas fluorescens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-hydroxy-L-kynurenine + H2O
-
Pseudomonas fluorescens 3-hydroxyanthranilate + L-alanine
-
?
3-hydroxy-L-kynurenine + H2O
-
Pseudomonas fluorescens 3-hydroxyanthranilate + L-Ala
-
?
L-alanine + pyridoxal 5'-phosphate
-
Pseudomonas fluorescens pyruvate + pyridoxamine 5'-phosphate
-
?
L-kynurenine + H2O
-
Pseudomonas fluorescens anthranilate + L-alanine
-
?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Pseudomonas fluorescens