BRENDA - Enzyme Database
show all sequences of 3.7.1.3

Inducible and constitutive kynureninases. Control of the inducible enzyme activity by transamination and inhibition of the constitutive enzyme by 3-hydroxyanthranilate

Tanizawa, K.; Soda, K.; J. Biochem. 86, 499-508 (1979)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
pyridoxal 5'-phosphate
in the presence of pyruvate
Neurospora crassa
pyridoxal 5'-phosphate
-
Sus scrofa
pyridoxamine phosphate
in the presence of pyruvate
Neurospora crassa
Application
Application
Commentary
Organism
medicine
tryptophan metabolism
Sus scrofa
medicine
tryptophan metabolism
Neurospora crassa
Inhibitors
Inhibitors
Commentary
Organism
Structure
3-Hydroxyanthranilate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
anthranilic acid
-
Neurospora crassa
delta-N-acetyl-L-ornithine
0.001 mM in 0.06 mM Tris-HCl buffer
Neurospora crassa
Kynurenate
-
Neurospora crassa
Kynurenate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
L-alanine
-
Neurospora crassa
L-lysine
-
Neurospora crassa
L-ornithine
-
Neurospora crassa
quinaldinate
-
Neurospora crassa
quinaldinate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
S-(beta-aminoethyl)-L-cysteine
0.001 mM in 0.06 mM Tris-HCl buffer
Neurospora crassa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
11
-
L-alanine
-
Neurospora crassa
40
-
L-ornithine
-
Neurospora crassa
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
105000
-
-
Neurospora crassa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-kynurenine + H2O
Sus scrofa
-
anthranilate + L-alanine
-
Sus scrofa
?
L-kynurenine + H2O
Neurospora crassa
-
anthranilate + L-alanine
-
Neurospora crassa
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Neurospora crassa
-
-
-
Sus scrofa
-
-
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
12.56
-
-
Neurospora crassa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-kynurenine + H2O
-
289267
Sus scrofa
anthranilate + L-alanine
-
289267
Sus scrofa
?
L-kynurenine + H2O
-
289267
Neurospora crassa
anthranilate + L-alanine
-
289267
Neurospora crassa
?
L-ornithine + H2O
-
289267
Neurospora crassa
?
-
289267
Neurospora crassa
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
pyridoxal 5'-phosphate
in the presence of pyruvate
Neurospora crassa
pyridoxal 5'-phosphate
-
Sus scrofa
pyridoxamine phosphate
in the presence of pyruvate
Neurospora crassa
Application (protein specific)
Application
Commentary
Organism
medicine
tryptophan metabolism
Sus scrofa
medicine
tryptophan metabolism
Neurospora crassa
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
3-Hydroxyanthranilate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
anthranilic acid
-
Neurospora crassa
delta-N-acetyl-L-ornithine
0.001 mM in 0.06 mM Tris-HCl buffer
Neurospora crassa
Kynurenate
-
Neurospora crassa
Kynurenate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
L-alanine
-
Neurospora crassa
L-lysine
-
Neurospora crassa
L-ornithine
-
Neurospora crassa
quinaldinate
-
Neurospora crassa
quinaldinate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
S-(beta-aminoethyl)-L-cysteine
0.001 mM in 0.06 mM Tris-HCl buffer
Neurospora crassa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
11
-
L-alanine
-
Neurospora crassa
40
-
L-ornithine
-
Neurospora crassa
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
105000
-
-
Neurospora crassa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-kynurenine + H2O
Sus scrofa
-
anthranilate + L-alanine
-
Sus scrofa
?
L-kynurenine + H2O
Neurospora crassa
-
anthranilate + L-alanine
-
Neurospora crassa
?
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
12.56
-
-
Neurospora crassa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-kynurenine + H2O
-
289267
Sus scrofa
anthranilate + L-alanine
-
289267
Sus scrofa
?
L-kynurenine + H2O
-
289267
Neurospora crassa
anthranilate + L-alanine
-
289267
Neurospora crassa
?
L-ornithine + H2O
-
289267
Neurospora crassa
?
-
289267
Neurospora crassa
?
Other publictions for EC 3.7.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733832
Phillips
The phosphate of pyridoxal-5'- ...
Pseudomonas fluorescens
FEBS J.
281
1100-1109
2014
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1
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1
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4
4
733495
Maitrani
Substituents effects on activi ...
Homo sapiens, Pseudomonas fluorescens
Bioorg. Med. Chem.
21
4670-4677
2013
-
2
2
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2
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2
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4
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2
2
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22
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20
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22
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2
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20
2
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3
3
-
20
20
719066
Feng
Ianthellamide A, a selective k ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
22
3398-3401
2012
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718881
Kumar
Substituent effects on the rea ...
Pseudomonas fluorescens
Biochemistry
49
7913-7919
2010
-
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1
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-
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1
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2
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1
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9
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7
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1
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1
1
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9
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7
-
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7
7
698102
Meng
Abnormal red body coloration o ...
Bombyx mori
Genes Cells
14
129-140
2009
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1
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1
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2
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4
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1
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1
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1
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699466
Lima
Crystal structure of the Homo ...
Homo sapiens
J. Med. Chem.
52
389-396
2009
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1
1
4
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2
8
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2
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1
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8
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4
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8
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8
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685134
Lima
Crystal structure of Homo sapi ...
Homo sapiens
Biochemistry
46
2735-2744
2007
-
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1
1
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1
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1
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3
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1
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1
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1
1
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3
-
1
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1
1
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688175
Christensen
Xanthurenic aciduria due to a ...
Homo sapiens
J. Inherit. Metab. Dis.
30
248-255
2007
-
1
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1
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1
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2
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3
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1
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1
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673094
Pellicciari
Modulators of the kynurenine p ...
Rattus norvegicus
ChemMedChem
1
528-531
2006
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3
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673130
Comai
The effect of age on the enzym ...
Rattus norvegicus
Clin. Chim. Acta
360
67-80
2005
-
1
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673365
Li
Screening a wide host-range, w ...
Escherichia coli, Rhizobium leguminosarum
Environ. Microbiol.
7
1927-1936
2005
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2
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2
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7
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658027
Momany
Three-dimensional structure of ...
Pseudomonas fluorescens
Biochemistry
43
1193-1203
2004
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4
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1
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658061
Gawandi
Reaction of Pseudomonas fluore ...
Pseudomonas fluorescens
Biochemistry
43
3230-3237
2004
-
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1
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2
2
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1
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2
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5
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1
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2
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1
-
5
-
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3
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673129
Allegri
Tryptophan metabolism along th ...
Oryctolagus cuniculus
Clin. Chim. Acta
350
41-49
2004
-
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4
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5
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5
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657495
Allegri
Kynurenine pathway enzymes in ...
Cavia porcellus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
Adv. Exp. Med. Biol.
527
455-463
2003
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11
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5
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5
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658345
Walsh
Comparative inhibition by subs ...
Homo sapiens, Pseudomonas fluorescens, Rattus norvegicus
BMC Biochem.
4
13
2003
-
3
1
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-
10
5
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1
5
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6
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3
3
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1
1
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8
-
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3
9
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3
1
3
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10
9
5
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1
5
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3
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1
1
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8
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660045
Heiss
Differential effects of bromin ...
Pseudomonas fluorescens
Org. Biomol. Chem.
1
288-295
2003
-
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6
3
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2
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1
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6
5
3
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1
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4
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658605
Walsh
Purification and biochemical c ...
Homo sapiens
Eur. J. Biochem.
269
2069-2074
2002
-
-
1
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3
1
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3
2
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3
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1
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1
3
3
1
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1
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1
3
-
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1
1
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3
3
1
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3
2
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1
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1
3
3
1
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-
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1
-
-
-
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-
-
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-
658274
Fitzgerald
A comparative study on the inh ...
Homo sapiens, Pseudomonas fluorescens
Bioorg. Med. Chem.
9
983-989
2001
-
2
1
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10
2
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4
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3
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2
1
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2
2
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8
-
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2
8
-
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2
1
2
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10
8
2
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4
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2
1
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2
2
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8
-
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289288
Cyr
Stereospecificity of Pseudomon ...
Pseudomonas fluorescens
Bioorg. Med. Chem.
7
1497-1503
1999
-
1
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2
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2
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2
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5
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1
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2
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5
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
289284
Fujigaki
Species differences in L-trypt ...
Meriones unguiculatus, Oryctolagus cuniculus
Arch. Biochem. Biophys.
358
329-335
1998
-
2
-
-
-
-
-
-
-
-
-
4
-
7
-
-
-
-
-
6
-
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6
-
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-
-
-
-
-
-
-
-
-
-
-
289285
Phillips
The catalytic mechanism of kyn ...
Pseudomonas fluorescens
Biochemistry
37
8783-8789
1998
-
1
-
-
-
-
5
-
-
-
-
2
-
2
-
-
1
-
-
-
-
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2
-
-
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-
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-
-
-
-
-
-
-
-
289286
Koushik
The catalytic mechanism of kyn ...
Pseudomonas fluorescens
Biochemistry
37
1376-1382
1998
-
1
-
-
-
-
3
-
-
-
-
3
-
2
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
289287
Drysdale
S-aryl cysteine S,S-dioxides a ...
Rattus norvegicus
Bioorg. Med. Chem. Lett.
8
133-138
1998
-
-
-
-
-
-
4
-
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-
2
-
2
-
-
-
-
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-
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-
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-
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-
-
-
-
-
-
-
-
-
289283
Koushik
Cloning, sequence, and express ...
Pseudomonas fluorescens
Arch. Biochem. Biophys.
34
301-308
1997
-
-
1
-
-
-
-
-
-
-
2
1
-
6
-
-
-
-
-
-
1
-
1
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-
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1
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1
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-
-
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-
-
-
-
-
-
-
-
-
-
-
289281
Moroni
Kynurenine hydroxylase and kyn ...
Rattus norvegicus
Adv. Exp. Med. Biol.
398
203-210
1996
-
1
-
-
-
-
4
-
-
-
-
1
-
1
-
-
-
-
-
2
-
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1
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-
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1
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
289282
Giordani
Benzoylalanine analogues as in ...
Rattus norvegicus
Adv. Exp. Med. Biol.
398
499-505
1996
-
1
-
-
-
-
8
-
-
-
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
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-
1
-
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-
-
-
-
8
-
-
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-
-
1
-
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-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
289280
Carpenedo
Inhibitors of kynurenine hydro ...
Rattus norvegicus
Neuroscience
61
237-244
1994
-
1
-
-
-
-
2
1
-
-
-
2
-
3
-
-
-
-
-
2
-
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3
-
-
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-
-
-
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-
-
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1
-
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-
-
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-
1
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2
-
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3
-
-
-
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-
-
-
-
-
-
-
-
289277
Shibata
On kynureninase activity ...
Rattus norvegicus
Adv. Exp. Med. Biol.
294
523-526
1991
-
-
-
-
-
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2
-
-
-
-
2
-
2
-
-
-
-
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1
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3
-
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-
-
-
-
-
289278
Okuno
Kynureninase and kynurenine 3- ...
Homo sapiens, Rattus norvegicus, Suncus murinus
Adv. Exp. Med. Biol.
294
167-176
1991
-
3
-
-
-
-
-
6
-
-
3
6
-
3
-
-
-
-
-
31
3
-
9
2
-
-
-
-
-
-
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-
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3
-
-
-
-
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-
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-
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3
6
-
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-
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3
-
9
2
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-
-
-
-
-
-
-
-
-
-
-
-
-
289279
Phillips
-
Stereochemistry and mechanism ...
Pseudomonas fluorescens
J. Am. Chem. Soc.
113
7385-7388
1991
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
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3
-
-
-
-
-
-
-
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1
-
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-
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3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
34546
Stevens
Isolation and characterization ...
Rattus norvegicus
J. Biol. Chem.
260
7945-7950
1985
-
1
-
-
-
-
-
2
-
-
1
2
-
2
-
-
1
-
-
2
1
-
3
1
-
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-
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1
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1
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1
2
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1
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1
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3
1
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-
-
-
-
-
-
-
-
-
289276
Palcic
Stereochemistry of the kynuren ...
Pseudomonas fluorescens
J. Biol. Chem.
260
5248-5251
1985
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
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-
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5
-
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1
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5
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-
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-
289273
Bild
Detection of beta-carbanion fo ...
Pseudomonas marginalis
Arch. Biochem. Biophys.
235
41-47
1984
-
-
-
-
-
-
-
-
-
-
-
1
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2
-
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1
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1
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1
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-
-
-
-
-
-
-
-
-
289274
Kishore
Mechanism-based inactivation o ...
Pseudomonas marginalis
J. Biol. Chem.
259
10669-10674
1984
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
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1
-
1
-
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-
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1
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-
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-
-
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-
-
-
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-
-
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-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
289271
Takeuchi
Purification and properties of ...
Rattus norvegicus
J. Biochem.
88
987-994
1980
-
1
-
-
-
-
-
-
1
-
2
-
-
2
-
-
1
-
-
2
1
1
-
1
-
-
-
-
1
-
-
-
-
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1
-
-
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-
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-
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1
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2
1
1
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
289272
Troost
Distinct kynureninase and hydr ...
Streptomyces parvulus
Biochim. Biophys. Acta
612
97-106
1980
-
1
-
-
-
-
-
-
-
-
1
2
-
2
-
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1
-
-
-
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3
-
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1
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-
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1
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-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
289266
Tanizawa
The mechanism of kynurenine hy ...
Pseudomonas fluorescens
J. Biochem.
86
1199-1209
1979
-
-
-
-
-
-
5
7
-
-
-
3
-
1
-
-
1
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8
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1
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1
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5
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7
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3
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1
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8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
289267
Tanizawa
Inducible and constitutive kyn ...
Neurospora crassa, Sus scrofa
J. Biochem.
86
499-508
1979
3
2
-
-
-
-
11
2
-
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1
2
-
5
-
-
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-
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1
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3
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-
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-
3
2
-
-
-
-
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-
11
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2
-
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1
2
-
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-
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1
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3
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
289268
Soda
Kynureninases: Enzymological p ...
amphibia, Aspergillus niger, aves, Bos taurus, Canis lupus familiaris, Cavia porcellus, Chondrichthyes, Homo sapiens, Mus musculus, Neurospora crassa, Penicillium roqueforti, Pseudomonas fluorescens, Pseudomonas marginalis, Rattus norvegicus, Rhizopus stolonifer, Saccharomyces cerevisiae, Testudines, Xanthomonas arboricola pv. pruni
Adv. Enzymol. Relat. Areas Mol. Biol.
49
1-40
1979
-
18
-
3
-
-
19
14
-
1
6
36
-
18
-
-
5
-
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12
1
-
57
3
-
-
-
-
4
-
-
4
-
-
-
-
18
-
4
3
-
-
-
19
-
14
-
1
6
36
-
-
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5
-
12
1
-
57
3
-
-
-
-
4
-
-
-
-
-
-
-
-
-
289269
Tanizawa
Comparison of inducible and co ...
Neurospora crassa
J. Biochem.
85
1367-1375
1979
-
1
-
1
-
-
-
2
-
-
1
2
-
7
-
-
1
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
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-
-
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1
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1
-
-
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2
-
-
1
2
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-
1
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
289270
Tanizawa
Purification and properties of ...
Sus scrofa
J. Biochem.
85
901-906
1979
-
-
-
-
-
-
11
4
-
-
1
-
-
2
-
-
1
-
-
2
1
-
1
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-
-
-
-
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
11
-
4
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1
-
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1
-
2
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
289265
Tanizawa
Crystalline inducible kynureni ...
Neurospora crassa
FEBS Lett.
70
235-238
1976
-
1
-
1
-
-
6
2
-
-
1
2
-
2
-
-
1
-
-
-
1
-
3
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
-
1
-
-
-
6
-
2
-
-
1
2
-
-
-
1
-
-
1
-
3
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
289264
Shetty
Kynureninase-type enzymes of P ...
Aspergillus niger, Penicillium roqueforti, Pseudomonas fluorescens, Rhizopus stolonifer
J. Bacteriol.
122
235-244
1975
-
4
-
-
-
-
-
6
-
-
-
8
-
11
-
-
4
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
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4
-
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-
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6
-
-
-
8
-
-
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4
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680422
Bouknight
Tryptophan catabolism in Bacil ...
Bacillus megaterium
J. Bacteriol.
121
70-76
1975
1
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
1
5
-
2
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
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-
-
-
1
-
-
-
-
-
1
5
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
289262
Moriguchi
-
Transamination reaction cataly ...
Pseudomonas marginalis
Biochemistry
12
1974-2980
1973
1
-
-
-
-
-
3
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
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-
1
-
-
-
-
-
-
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3
-
-
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-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
289263
Moriguchi
Properties of crystalline Kynu ...
Pseudomonas marginalis
Biochemistry
12
2969-2974
1973
-
-
-
1
-
-
8
1
-
-
2
1
-
2
-
-
1
-
-
-
-
1
1
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
1
1
-
-
-
8
-
1
-
-
2
1
-
-
-
1
-
-
-
1
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
289261
Wiss
-
Die Reindarstellung der Kynure ...
Sus scrofa
Hoppe-Seyler's Z. Physiol. Chem.
304
232-240
1956
-
1
-
-
-
-
-
-
-
-
-
2
-
1
-
-
1
-
-
1
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
1
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
289258
Jacoby
Kynureninase from Neurospora: ...
Neurospora crassa
J. Biol. Chem.
205
709-715
1953
-
-
-
-
-
-
26
-
-
-
-
2
-
2
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
26
-
-
-
-
-
2
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
289259
Jacoby
Kynureninase from Neurospora: ...
Neurospora crassa
J. Biol. Chem.
205
699-707
1953
-
-
-
-
-
-
6
2
-
2
-
2
-
2
-
-
1
-
-
-
-
-
4
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
1
-
-
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6
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289260
Knox
The relation of liver kynureni ...
Rattus norvegicus
Biochem. J.
53
379-385
1952
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