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Literature summary for 3.7.1.2 extracted from
- Inhibition of fumarylacetoacetate fumarylhydrolase by monovalent anions (1973), Biochemistry, 12, 4878-4881.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-benzoylpropionate | 1 mM, 40% inhibition | Bos taurus |  |
| 4-ethyl oxaloacetate | 1 mM, 30% inhibition | Bos taurus | |
| 4-ketopimelate | 1 mM, 10% inhibition | Bos taurus | |
| acetoacetate | 1 mM, 30% inhibition | Bos taurus | |
| alpha-Ketobutyrate | 1 mM, 50% inhibition | Bos taurus | |
| alpha-ketoglutarate | 1 mM, 50% inhibition | Bos taurus | |
| Br- | 50 mM for 50% inhibition | Bos taurus | |
| Cl- | 140 mM for 50% inhibition | Bos taurus | |
| ClO4- | 6 mM for 50% inhibition | Bos taurus | |
| Dihydroxytartrate | 1 mM, 100% inhibition | Bos taurus | |
| F- | 1.2 mM for 50% inhibition | Bos taurus | |
| HCO3- | 170 mM for 50% inhibition | Bos taurus | |
| NO3- | 12 mM for 50% inhibition | Bos taurus | |
| oxaloacetate | 1 mM, 90% inhibition | Bos taurus | |
| pyruvate | - |
Bos taurus | |
| SCN- | 4.2 mM for 50% inhibition | Bos taurus | |
| trichloroacetate | 1.2 mM for 50% inhibition | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-fumarylacetoacetate + H2O | Bos taurus | - |
acetoacetate + fumarate | - |
? | |
| pyruvate + H2O | Bos taurus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-benzoylpropionate + H2O | - |
Bos taurus | benzoate + propionate | - |
? | |
| 4-ethyl oxaloacetate + H2O | - |
Bos taurus | ? | - |
? | |
| 4-fumarylacetoacetate + H2O | - |
Bos taurus | acetoacetate + fumarate | - |
? | |
| 4-ketopimelate + H2O | - |
Bos taurus | succinate + propanoate | - |
? | |
| acetoacetate + H2O | - |
Bos taurus | acetate | - |
? | |
| alpha-ketobutyrate + H2O | - |
Bos taurus | ? | - |
? | |
| alpha-ketoglutarate + H2O | - |
Bos taurus | ? | - |
? | |
| dihydroxytartrate + H2O | - |
Bos taurus | ? | - |
? | |
| oxaloacetate + H2O | - |
Bos taurus | ? | - |
? | |
| propionopyruvate + H2O | - |
Bos taurus | ? | - |
? | |
| pyruvate + H2O | - |
Bos taurus | ? | - |
? | |
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Release 2023.1 (January 2023)
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