Literature summary for 3.7.1.17 extracted from

Van Der Geize, R.; Yam, K.; Heuser, T.; Wilbrink, M.; Hara, H.; Anderton, M.; Sim, E.; Dijkhuizen, L.; Davies, J.; Mohn, W.; Eltis, L.
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages (2007), Proc. Natl. Acad. Sci. USA, 104, 1947-1952.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli strain GJ1158	Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.019	-	2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoic acid	in 20 mM HEPES, 80 mM NaCl, at pH 8.0 and 25°C	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-
Mycobacterium tuberculosis H37Rv	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O	-	Mycobacterium tuberculosis	?	-	?
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O	-	Mycobacterium tuberculosis H37Rv	?	-	?
4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid + H2O	the apparent specificity for 4,59,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid is 34fold higher than for 2-hydroxy-6-oxo-6-phenylpentadienoate	Mycobacterium tuberculosis	9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid + ?	-	?
4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid + H2O	the apparent specificity for 4,59,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid is 34fold higher than for 2-hydroxy-6-oxo-6-phenylpentadienoate	Mycobacterium tuberculosis H37Rv	9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid + ?	-	?

Synonyms

Synonyms	Comment	Organism
HsaD	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)