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Literature summary for 3.6.5.6 extracted from
- Enhancement of tubulin polymerization by Cl--induced blockade of intrinsic GTPase (2012), Biochem. Biophys. Res. Commun., 425, 225-229.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Br- | - |
Sus scrofa |  |
| Cl- | enhancement of tubulin polymerization by Cl--induced blockade of intrinsic GTPase. GTPase activity of tubulin is lower (2/3-fold) in Cl--containing solutions than that in Cl--free solutions containing Br- or NO3- | Sus scrofa | |
| NO3- | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microtubule | - |
Sus scrofa | 5874 | - |
| neurite | - |
Sus scrofa | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Sus scrofa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Sus scrofa | - |
GDP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Sus scrofa | - |
| neuron | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Sus scrofa | GDP + phosphate | - |
? | |
| additional information | efficiency of in vitro tubulin polymerization in solutions containing a non-hydrolyzable analogue of GTP, GpCpp, instead of GTP is much higher than that in the presence of GTP | Sus scrofa | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Sus scrofa |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enhancement of tubulin polymerization by Cl--induced blockade of intrinsic GTPase | Sus scrofa |
| physiological function | a part of stimulatory effects of Cl- on in vitro tubulin polymerization is mediated via an inhibitory effect on GTPase activity of tubulin, although Cl- also regulates in vitro tubulin polymerization by factors other than an inhibitory effect on GTPase activity | Sus scrofa |
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