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Literature summary for 3.6.5.6 extracted from
- Rotenone inhibits mammalian cell proliferation by inhibiting microtubule assembly through tubulin binding (2007), FEBS J., 274, 4788-4801.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| rotenone | rotenone inhibits both the assembly and the GTP hydrolysis rate of microtubules in vitro | Capra hircus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Capra hircus | - |
GDP + phosphate | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Capra hircus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| MAP-free tubulin is purified from the microtubule protein of goat brain by phosphocellulose chromatography | Capra hircus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Capra hircus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Capra hircus | GDP + phosphate | - |
ir | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
GTPase activity assay | Capra hircus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
GTPase activity assay | Capra hircus |
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Release 2023.1 (January 2023)
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