Literature summary for 3.6.5.6 extracted from

Gupta, K.K.; Bharne, S.S.; Rathinasamy, K.; Naik, N.R.; Panda, D.
Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding (2006), FEBS J., 273, 5320-5332.

Search for more literature for 3.6.5.6

Inhibitors

Inhibitors	Comment	Organism	Structure
curcumin	-	Capra hircus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GTP + H2O	Capra hircus	-	GDP + phosphate	-	ir

Organism

Organism	UniProt	Comment	Textmining
Capra hircus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
goat brain microtubule protein is isolated by two cycles of polymerization and depolymerization, MAP-free tubulin is purified from the microtubule protein by phosphocellulose chromatography	Capra hircus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Capra hircus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
5.6	-	in the presence of 50 microM curcumin	Capra hircus
7.1	-	-	Capra hircus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + H2O	-	Capra hircus	GDP + phosphate	-	ir

Subunits

Subunits	Comment	Organism
heterodimer	alpha-beta dimer	Capra hircus

Synonyms

Synonyms	Comment	Organism
tubulin GTPase	-	Capra hircus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	GTPase assay	Capra hircus

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Release 2023.1 (January 2023)