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Literature summary for 3.6.5.6 extracted from
- Calcium and gadolinium ions stimulate the GTPase activity of purified chicken brain tubulin through a conformational change (1996), Biochemistry, 35, 6337-6344.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | induction of the GTPase activity of brain tubulin, inhibition of tubulin assembly, prevents tubulin polymerization and induces rapid depolymerization of preformed microtubules | Gallus gallus |  |
| Gd3+ | stimulates the GTPase activity of brain tubulin, inhibits tubulin polymerization and induce microtubule depolymerization | Gallus gallus | |
| Nd3+ | stimulates the GTP hydrolysis, inhibits tubulin polymerization and induces microtubule depolymerization | Gallus gallus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Gallus gallus | - |
GDP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
chicken | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Gallus gallus | GDP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Gallus gallus |
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