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Literature summary for 3.6.5.5 extracted from

  • Ishida, N.; Nakamura, Y.; Tanabe, K.; Li, S.A.; Takei, K.
    Dynamin 2 associates with microtubules at mitosis and regulates cell cycle progression (2011), Cell Struct. Funct., 36, 145-154.
    View publication on PubMed
Search for more literature for 3.6.5.5

Cloned(Commentary)

Cloned (Comment) Organism
expression of GFP-tagged or V5/His-tagged wild-type and K44A mutant dynamin 2aa in HeLa cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
K44A a dominant-negative mutation, blocks cytokinesis and membrane trafficking, but does not affect endocytosis, the mutant has no effect on microtubules Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule dynamin 2 Rattus norvegicus 5874
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additional information localization of dynamin 2 depends on its Pro-rich domain, immunohistochemic determination of dynamin 2 localization during mitosis, overview Rattus norvegicus
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spindle dynamin 2 Rattus norvegicus 5819
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
-

Synonyms

Synonyms Comment Organism
dynamin 2
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 Rattus norvegicus
dynamin 2aa
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 Rattus norvegicus

General Information

General Information Comment Organism
malfunction deletion of dynamin middle domain blocks binding to gamma-tubulin and impairs entry into mitosis, but does not affect endocytosis Rattus norvegicus
physiological function dynamin 2 GTPase is a key player in membrane traffic and clathrin-mediated endocytosis, molecular mechanism, overview. It also regulates the dynamic instability of microtubules by a membrane traffic-independent mechanism. Dynamin may play a key role in cell cycle progression by regulating the microtubules Rattus norvegicus