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Literature summary for 3.6.5.5 extracted from

  • Wells, R.C.; Picton, L.K.; Williams, S.C.; Tan, F.J.; Hill, R.B.
    Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm (2007), J. Biol. Chem., 282, 33769-33775.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.5

Application

Application Comment Organism
medicine three autosomal dominant neuropathies in humans are caused by defects in mitochondrial fusion, and a defect in mitochondrial fission is reported as being lethal, mitochondrial morphology is proposed to be maintained by a balance of mitochondrial fusion and fission involving at least four dynamin-like GTPases Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
DNA encoding the full-length Dnm1 protein is cloned into the pMALc2x vector for expression in Escherichia coli Rosetta cells Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Saccharomyces cerevisiae 5739
-
peroxisome
-
 Saccharomyces cerevisiae 5777
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Saccharomyces cerevisiae
-
 GDP + phosphate
-
 ir

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using amylose affinity chromatography, cleavage of the MBP fusion tag Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Saccharomyces cerevisiae GDP + phosphate
-
 ir

Synonyms

Synonyms Comment Organism
DLP1
-
 Saccharomyces cerevisiae
Dnm1
-
 Saccharomyces cerevisiae
Drp1
-
 Saccharomyces cerevisiae
dynamin-like GTPase
-
 Saccharomyces cerevisiae