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Literature summary for 3.6.5.3 extracted from
- The magic spot ppGpp influences in vitro the molecular and functional properties of the elongation factor 1alpha from the archaeon Sulfolobus solfataricus (2012), Extremophiles, 16, 743-749.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| guanosine 5'-tetraphosphate | competitive inhibition of intrinsic GTPase, inhibition of archaeal protein synthesis in vitro, even though the concentration required to get inhibition is higher than that required for the eubacterial and eukaryal systems | Saccharolobus solfataricus |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | GTPase activity is measured in the presence of 3.6 M NaCl | Saccharolobus solfataricus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Saccharolobus solfataricus | - |
GDP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharolobus solfataricus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Saccharolobus solfataricus | GDP + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| elongation factor 1alpha | - |
Saccharolobus solfataricus |
| SsEF-1alpha | - |
Saccharolobus solfataricus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 75 | - |
assay at | Saccharolobus solfataricus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 96 | - |
binding of guanosine 5'-tetraphosphate to SsEF-1alpha renders the elongation factor more resistant to heat treatment. The denaturation profile of the elongation factor in the presence of guanosine tetraphosphate is shifted towards higher temperatures with a denaturation midpoint (96.4°C) about 2°C higher with respect to that observed for the elongation factor bound to GDP | Saccharolobus solfataricus |
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