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Literature summary for 3.6.5.3 extracted from

  • Lamberti, A.; Martucci, N.M.; Ruggiero, I.; Arcari, P.; Masullo, M.
    Interaction between the antibiotic tetracycline and the elongation factor 1alpha from the archaeon Sulfolobus solfataricus (2011), Chem. Biol. Drug Des., 78, 260-268.
    View publication on PubMed
Search for more literature for 3.6.5.3

Inhibitors

Inhibitors Comment Organism Structure
tetracycline mixed inhibition. The inhibition level depends on the antibiotic concentration, even though a complete inhibition is not reached even in the presence of 0.120 mM antibiotic, a concentration corresponding to about 200fold molar excess over the elongation factor Saccharolobus solfataricus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0025
-
 GTP pH 7.8, 60°C Saccharolobus solfataricus

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Saccharolobus solfataricus GDP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
elongation factor 1alpha
-
 Saccharolobus solfataricus
SsEF-1alpha
-
 Saccharolobus solfataricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
 assay at Saccharolobus solfataricus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.5
-
 GTP pH 7.8, 60°C Saccharolobus solfataricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Saccharolobus solfataricus