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Literature summary for 3.6.5.2 extracted from

  • Rousset, M.; Cens, T.; Menard, C.; Bowerman, M.; Bellis, M.; Bruses, J.; Raoul, C.; Scamps, F.; Charnet, P.
    Regulation of neuronal high-voltage activated CaV2 Ca2+ channels by the small GTPase RhoA (2015), Neuropharmacology, 97, 201-209.
    View publication on PubMed
Search for more literature for 3.6.5.2

Cloned(Commentary)

Cloned (Comment) Organism
heterologous expression of RhoA in Xenopus laevis oocytes. Expression of constitutively active RhoA in primary culture of spinal motoneurons also drastically reduces high-voltage-activated Ca2+ current amplitude Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information RhoA- or ROCK-induced inhibitions are partially relieved upon incubation of the oocytes with the ROCK inhibitor Y27632 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Mus musculus
-
 GDP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9QUI0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron constitutively active RhoA in primary culture of spinal motoneurons Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Mus musculus GDP + phosphate
-
 ?
additional information recombinant RhoA activity reduces Ba2+ currents through CaV2.1, CaV2.2 and CaV2.3 Ca2+ channels independently of CaVbeta subunit. This inhibition occurs independently of RGKs activity and without modification of biophysical properties and global level of expression of the channel subunit Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
RhoA
-
 Mus musculus
small GTPase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction expression of constitutively active RhoA in primary culture of spinal motoneurons also drastically reduces high-voltage-activated Ca2+ current amplitude Mus musculus
metabolism high-voltage-activated Ca2+ channels are known regulators of synapse formation and transmission and play fundamental roles in neuronal pathophysiology. Small GTPases of Rho and RGK families, via their action on both cytoskeleton and Ca2+ channels are key molecules for these processes Mus musculus
physiological function RhoA inhibits HVA CaV2 Ca2+ channels in a CaVbeta subunit-independent manner, recombinant RhoA activity reduces Ba2+ currents through CaV2.1, CaV2.2 and CaV2.3 Ca2+ channels independently of CaVbeta subunit. This inhibition occurs independently of RGKs activity and without modification of biophysical properties and global level of expression of the channel subunit. High-voltage-activated Ca2+ channels regulation by RhoA might govern synaptic transmission during development and potentially contribute to pathophysiological processes when axon regeneration and growth cone kinetics are impaired. Effects of RhoA on CaV2 trafficking to the plasma membrane, regulation of Ca2+ channel expression and activity by small GTPases, overview Mus musculus