Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of Cdc42-deficient B cells, tamoxifen induction of Cdc42 excision | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Mus musculus | - |
GDP + phosphate | - |
? | |
GTP + H2O | Mus musculus C57BL/6 | - |
GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Cdc42flox mice | - |
Mus musculus C57BL/6 | - |
Cdc42flox mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B-lymphocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Mus musculus | GDP + phosphate | - |
? | |
GTP + H2O | - |
Mus musculus C57BL/6 | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cdc42 | - |
Mus musculus |
Rho GTPase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of Cdc42 in mature B cells results in an antibody response of reduced magnitude and lower affinity to soluble T cell-dependent antigen. B cells that lack Cdc42 remain dominant for 2 weeks postinduction with tamoxifen, following which Cdc42-sufficient B cells gradually dominate with very few Cdc42-deficient B cells being detected after 6 weeks. Deletion of Cdc42 in mature B cells alters their ability to activate T cells. B cells that lack Cdc42 fail to form long protrusions on Ab-coated surfaces. Reduced spreading and upregulation of CIP4 in Cdc42-deficient B cells. Deletion of Cdc42 in B cells leads to impaired humoral immune response, phenotype, overview | Mus musculus |
physiological function | role of intrinsic expression of Cdc42 by mature B cells in their activation and function, Cdc42 expression in B cells is essential for efficient IL-2 secretion of CD4+ T cells in cognate T-B cell interaction | Mus musculus |