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Literature summary for 3.6.5.2 extracted from

  • Gerasimcik, N.; Dahlberg, C.I.; Baptista, M.A.; Massaad, M.J.; Geha, R.S.; Westerberg, L.S.; Severinson, E.
    The Rho GTPase Cdc42 is essential for the activation and function of mature B cells (2015), J. Immunol., 194, 4750-4758.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information generation of Cdc42-deficient B cells, tamoxifen induction of Cdc42 excision Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Mus musculus
-
GDP + phosphate
-
?
GTP + H2O Mus musculus C57BL/6
-
GDP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
Cdc42flox mice
-
Mus musculus C57BL/6
-
Cdc42flox mice
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
Mus musculus GDP + phosphate
-
?
GTP + H2O
-
Mus musculus C57BL/6 GDP + phosphate
-
?

Synonyms

Synonyms Comment Organism
Cdc42
-
Mus musculus
Rho GTPase
-
Mus musculus

General Information

General Information Comment Organism
malfunction deletion of Cdc42 in mature B cells results in an antibody response of reduced magnitude and lower affinity to soluble T cell-dependent antigen. B cells that lack Cdc42 remain dominant for 2 weeks postinduction with tamoxifen, following which Cdc42-sufficient B cells gradually dominate with very few Cdc42-deficient B cells being detected after 6 weeks. Deletion of Cdc42 in mature B cells alters their ability to activate T cells. B cells that lack Cdc42 fail to form long protrusions on Ab-coated surfaces. Reduced spreading and upregulation of CIP4 in Cdc42-deficient B cells. Deletion of Cdc42 in B cells leads to impaired humoral immune response, phenotype, overview Mus musculus
physiological function role of intrinsic expression of Cdc42 by mature B cells in their activation and function, Cdc42 expression in B cells is essential for efficient IL-2 secretion of CD4+ T cells in cognate T-B cell interaction Mus musculus